IL-17、IgA、IgE在过敏性紫癜患儿中的表达及影响患儿复发的危险因素分析

目的 分析白介素-27(Interleukin-27,IL-27)、免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白E(Immunoglobulin E,IgE)在过敏性紫癜(allergic purpura, HSP)患儿中的表达及影响患儿复发的危险因素。方法 收集本院2020年5月至2021年2月本院收治的HSP患儿103例(HSP组),另选取本院同期健康体检者97例(对照组)。对比不同人群中IL-17、IgA、IgE表达水平，收集患儿一般资料，分析影响HSP患儿复发危险因素。结果 HSP患儿IL-17(88.26±15.24 pg/mL)、IgA(8.59±1.38 g/L)、IgE(1.66±0.35 mg/L)表达水平均明显高于对照组[IL-17(51.21±15.10 pg/mL)、IgA(1.11±0.15 g/L)、IgE(0.38±0.16 mg/L)],差异均有统计学意义(P<0.05);103例患儿在治疗后1周后复发35例(33.33%),未复发68例，经logistic回归模型分析中发现，年龄(OR=1.339,95%CI:1.028～...

Expression of IL-17, IgA,IgE in children with Henoch-Schonlein purpura and risk factors affecting the recurrence of children

Objective To analyze the expression of interleukin-27 (IL-27), immunoglobulin A (IgA) and immunoglobulin E (IgE) in children with Henoch-Schonlein purpura (HSP) and the risk factors affecting the recurrence of children. Methods A total of 103 children with HSP admitted to this hospital from May 2020 to February 2021 were collected (HSP group). In addition, 97 children with healthy physical examination in this hospital during the same period were selected (control group). The expression levels of IL-17, IgA, and IgE in different populations were compared and general patient data were collected to analyze the risk factors of recurrence in children with HSP. Results The expression levels of IL-17 (88.26±15.24 pg/mL), IgA (8.59±1.38 g/L), and IgE (1.66±0.35 mg/L) in children with HSP were significantly higher than those in the control group ［IL-17 (51.21±15.10 pg/mL), IgA (1.11±0.15 g/L), IgE (0.38±0.16 mg/L)］, and the differences were statistically significant (P<0.05). Among the 103 patients, 35 patients (33.33%) relapsed one week after treatment, and 68 patients did not relapse. Substituting the statistically significant factors in the single factor into the conditional logistic regression model analysis found that age (OR=1.339, 95%CI: 1.028-1.903), persistent/frequent/repeated rash (OR=1.345, 95%CI: 1.078-1.679), infection (OR=1.218, 95%CI: 0.897-1.654), IL-17 (OR=1.66, 95%CI: 1.091-2.545), IgA (OR=1.430, 95%CI: 1.005-2.035), IgE (OR=1.375, 95%CI: 1.064-1.778) were risk factors for recurrence after HSP treatment (P<0.05). Conclusion All the expressions of IL-17, IgA and IgE in HSP increase significantly, and the three are risk factors that affect the recurrence of children. The detection of changes in the levels of the three can provide certain reference information for the prognostic evaluation of patients, and targeted prevention of related risks can be carried out in clinical practice to reduce the recurrence rate.