Systemic risk factors for peri-implant bone loss: a systematic review and meta-analysis |
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| Affiliation: | 1. Department of Dentistry, University “Tor Vergata”, Rome, Italy;2. Oral Biology Program, Implantodontics, Sagrado Coração University, Bauru, Sao Paulo, Brazil;3. Department of Oral Surgery, University of Valencia, Valencia, Spain;4. Independent Researcher, Rome, Italy;5. Department of Prosthodontics, Bauru Dental School, Sao Paulo University, Bauru, Sao Paulo, Brazil;1. Department of Oral Surgery, Medical University of Vienna, Austria;2. Austrian Cluster for Tissue Regeneration, Vienna, Austria;3. Ludwig Boltzmann Cluster for Cardiovascular Research, Medical University of Vienna, Austria;4. Institute of Physiological Chemistry, Center of Physiological Medicine, Medical University Graz, Austria;5. School of Dental Medicine, University of Bern, Switzerland;1. Department of Oral Surgery, University of Planalto Catarinense (UNIPLAC), Lages, Santa Catarina, Brazil;2. Postgraduate Department, Latin American Institute of Dental Research and Education (ILAPEO), Curitiba, Paraná, Brazil;3. Department of Oral Surgery, State University of São Paulo (UNESP), Araçatuba, São Paulo, Brazil;4. Latin American Institute of Dental Research and Education (ILAPEO), Curitiba, Paraná, Brazil;1. Lecturer, Department of surgical and diagnostic sciences, University of Genova, Genova, Italy;2. Lecturer, Dental Institute Toscano, Viareggio, Italy;3. Professor, Periodontology Department, Vita-Salute University Milano, Milan, Italy;4. Professor, Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Dental School, Ghent University, Ghent, Belgium;5. Professor, Department of Periodontology and Oral Implantology, Faculty of Medicine and Health Sciences, Dental School, Ghent University, Ghent, Belgium; and Professor, Department of Periodontology and Oral Implantology, Vrije Universiteit Brussel (VUB) Belgium, Brussels, Belgium;6. Professor, Department of Surgical and Diagnostic Sciences, Division of Prosthodontics, University of Genova, Genova, Italy;1. Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden;2. Department of Biomaterials, Göteborg University, Göteborg, Sweden;1. Specialty registrar, Department of Restorative Dentistry, Charles Clifford Dental Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, and Doctoral student, School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom;2. Professor of Psychology as applied to Dentistry, School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom;3. Academic clinical lecturer in restorative dentistry, School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom;4. Professor and Honorary Consultant in Restorative Dentistry, School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom;5. Senior Lecturer in Dental Public Health, School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom |
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| Abstract: | The aim of this study was to determine the influence of patient-related systemic risk factors (systemic disease, genetic traits, chronic drug or alcohol consumption, and smoking status) on peri-implant bone loss at least 1 year after implant installation and prosthetic loading. An electronic search was performed of MEDLINE, EMBASE, and The Cochrane Central Register of Controlled Trials up to January 2012. One thousand seven hundred and sixty-three studies were identified. After applying a three-stage screening process, 17 articles were included in the qualitative analysis, but only 13 in the quantitative analysis, since smoking was a common exposure. The meta-analysis of these 13 studies (478 smokers and 1207 non-smokers) revealed a high level of heterogeneity and that smoking increases the annual rate of bone loss by 0.164 mm/year. Exposure to smoking had a harmful effect on peri-implant bone loss. However, the level of evidence for oral implant therapy in patients with systemic conditions is very low. Future studies should be improved in order to provide more robust data for clinical application. |
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| Keywords: | bone loss risk factors meta-analysis systemic diseases smoking dental implants |
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