Psychiatric symptoms in boys with fragile X syndrome: A comparison with nonsyndromic autism spectrum disorder |
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| Affiliation: | 1. MIND Institute, University of California, Davis, United States;2. Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States;3. Department of Pediatrics, University of California, Davis, United States;1. University Ramon Llull, c/ Císter, 34, 08022 Barcelona, Spain;2. CPT Estel, c/ Jaume I el Conqueridor, 19, 08500 Vic, Spain;3. University of Barcelona, Ps. de la Vall d’Hebron, 171, 08035 Barcelona, Spain;4. University of Girona, Campus Montilivi, 17071 Girona, Spain;1. Department of Child Neuropsychiatry, Sapienza University of Rome, Via dei Sabelli 108, 00185 Rome, Italy;2. Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D-79104 Freiburg i. Br., Germany;1. Child Clinical Neuropsychology Unit, Department of Psychology, University of Geneva, Geneva, Switzerland;2. Methodology and Data Analysis Unit, Department of Psychology, University of Geneva, Geneva, Switzerland;3. Psychology and Pedagogy of the Handicapped Person, Department of Psychology: Cognition and Behavior, University of Liège, Belgium;1. School of Psychiatry and Psychology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3800, Australia;2. Genetics Education and Health Research, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia;3. Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3025, Australia;4. Victorian Clinical Genetics Services, Flemington Rd, Parkville, Victoria 3052, Australia;5. Centre for Developmental Disability Health Victoria, Monash University, Clayton, Victoria 3800, Australia;6. Fragile X Alliance Inc., Clinic and Resource Centre, 263 Glen Eira Road, North Caulfield, Victoria 3161, Australia;7. Department of Developmental Disability Neuropsychiatry and Centre for Health Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia;8. Olga Tennison Autism Research Centre, School of Psychological Science, La Trobe University, Bundoora 3086, Australia |
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| Abstract: | In the present study, we examined the profile of psychiatric symptoms in boys with fragile X syndrome (FXS) using a parent report instrument. In addition, by comparing boys with FXS to boys with nonsyndromic autism spectrum disorder (ASD) utilizing multiple matching strategies, we examined between-group differences in the types of psychiatric symptoms observed and in the strength of their concurrent associations. Across all matching strategies, symptoms of manic/hyperactive behaviors and general anxiety were more frequently reported for boys with FXS than for boys with nonsyndromic ASD. Results also indicated a positive association between social avoidance and general anxiety in FXS that was stronger than that observed in nonsyndromic ASD across all matching strategies. Theoretical and treatment implications are discussed. |
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| Keywords: | Fragile X syndrome Autism spectrum disorder Anxiety Hyperactivity Social avoidance Psychiatric symptoms |
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