Disrupted sensorimotor synchronization,but intact rhythm discrimination,in children treated for a cerebellar medulloblastoma |
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| Affiliation: | 1. Laboratoire CHArt, EPHE, Paris, France;2. Université Paris-Sud, Centre de Neurosciences Paris-Sud, UMR 8195, Orsay 91405, France;3. CNRS, Orsay 91405, France;4. Université Blaise Pascal, CNRS, UMR 6024, Clermont-Ferrand, France;5. Département de Cancérologie de l’Enfant et de l’Adolescent, Institut Gustave Roussy et Université Paris-Sud XI, Villejuif, France;6. Hôpitaux de Saint-Maurice, Centre de Suivi et d’insertion, Saint-Maurice, France;7. Inserm U669, Université Paris Sud, Université Paris Descartes, France;8. The Graduate Center, CUNY, and the Department of Psychology, Queens College, Flushing, NY, USA;1. Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland;2. Neuroscience Center Zurich, University of Zurich, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland;3. Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland;4. Department of Psychology, Ludwig Maximilian University Munich, Munich, Germany;5. Takeda Pharmaceuticals International, Cambridge, Massachusetts;6. Pfizer Worldwide Research and Development, Cambridge, Massachusetts;7. Cerevel Therapeutics, Boston, Massachusetts;1. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, WC1N 3BG, UK;2. fMRI Unit, IRCCS Galeazzi, 20161, Milan, Italy;1. Department of Speech, Language, and Hearing, Behavioral and Brain Sciences, The University of Texas at Dallas, United States;2. Callier Center for Communication Disorders, The University of Texas at Dallas, United States;3. Center for BrainHealth, University of Texas at Dallas, United States;4. Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, United States;1. Servicio de Radiología, Hospital Universitario Central de Asturias, Facultad de Medicina, Departamento de Medicina, Universidad de Oviedo, Asturias, Spain;2. Departamento de Construcción e Ingeniería de Fabricación, Universidad de Oviedo, Asturias, Spain;3. IUOPA-Área de Medicina Preventiva y Salud Pública, Departamento de Medicina, Universidad de Oviedo, Asturias, Spain;4. Editor del blog, MIRentrelazados, Zaragoza, Spain;5. Servicio de Radiología, Hospital Universitario Central de Asturias, Asturias, Spain;6. Director del Curso Intensivo MIR Asturias, Oviedo, Asturias, Spain;1. Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA;2. Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA;3. Department of Otolaryngology, Washington University in St. Louis, St. Louis, MO, USA |
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| Abstract: | The aim of this study was to investigate the temporal abilities of children treated by surgery for a malignant tumor in the cerebellum, both in the perception and the production of rhythm. Children with a diagnosed medulloblastoma and age-matched control children were tested in a rhythm discrimination task and a sensorimotor synchronization task. Their motor and cognitive capabilities were also assessed through a battery of age-adapted neuropsychological tests. The results did not show any significant difference in performance between groups for the discrimination task. On the contrary, children with cerebellar lesions produced longer and more variable inter-tap intervals (ITI) in their spontaneous motor tempo (SMT) than did the control children. However, the length and, to a lesser extent, the variability of their SMT decreased after a synchronization phase, when they had been instructed to tap in synchrony with a beep. During the synchronization task, the children with medulloblastoma succeeded to modify the length of their ITI in response to an auditory rhythm, although with better success when the inter-stimuli intervals (ISI) were shorter than when they were longer than the ITIs of their own SMT. Correlational analyses revealed that children's poorer synchronization performance was related to lower scores in neuropsychological tests assessing motor dexterity and processing speed. |
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| Keywords: | Rhythm Synchronization Cerebellum Lesion Children |
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