Association of dopamine gene variants,emotion dysregulation and ADHD in autism spectrum disorder |
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| Institution: | 1. Department of Psychiatry, Stony Brook University, Stony Brook, NY 11794-8790, United States;2. Department of Pharmacology, Center in Pharmacogenomics, Ohio State University Wexner Medical Center, 333 West 10th Avenue, Columbus 43210, United States;1. Indiana University School of Medicine, Riley Hospital for Children;2. Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center;3. Nathan Kline Institute for Psychiatric Research;4. Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre;5. Center for the Developing Brain, Child Mind Institute;6. Fordham University;1. FOM University of Applied Sciences, Birlenbacher Str. 17, D-57078 Siegen, Germany;2. Department of Clinical Child and Adolescent Psychology and Psychotherapy, Philipps University Marburg, Germany;1. IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Viale del Tirreno 331, 56128, Calambrone, Italy;2. Department of Psychology, Centre for Innovation in Mental Health, University of Southampton, Highfield Campus, Clinical and Experimental Sciences (CNS and Psychiatry) and Solent NHS Trust, Southampton SO17 1BJ, UK;3. New York University Child Study Center, One Park Ave, 7th floor, New York City, New York 10016, USA;1. Queen’s Genomics Lab at Ongwanada (QGLO), Ongwanada Resource Center, Kingston, Ontario, Canada;2. Department of Psychiatry, Queen’s University, Kingston, Ontario, Canada;3. Department of Psychology, Queen’s University, Kingston, Ontario, Canada;4. Department of Psychology, Qingdao University, Qingdao, Shandong, China;1. Service of psychiatric specialties, Department of mental Health and Psychiatry, University Hospitals of Geneva, Geneva, Switzerland;2. Department of Cardiology and Endodontology, Treatment Plan Unit and Division of Operative Dentistry, Dental School, University of Geneva, Geneva, Switzerland;3. Department of Psychiatry, University of Geneva, Geneva, Switzerland;4. Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France;5. Université Paris Est, Faculté de Médecine, Créteil 94000, France;6. AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d’Addictologie, Créteil 94000, France;7. Fondation Fondamental, Créteil 94000, France;8. AP-HP, GH Saint-Louis - Lariboisière - Fernand Widal, Pôle Neurosciences, 75010 Paris, France;9. Université Paris Diderot, UMR-S 1144, 75006 Paris, France;10. Hôpital Charles Perrens, Service de psychiatrie adulte, Pôle 3-4-7, 33000 Bordeaux, France;11. Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy 54500, France;12. Institut Pasteur, Unité Perception et Mémoire, 75015 Paris, France;1. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstraße 50, 60528 Frankfurt am Main, Germany;2. Interdisciplinary Centre Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen, CC 72, P.O. Box 30.001, 9700 RB Groningen, the Netherlands;3. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt am Main, Germany |
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| Abstract: | The aim of the present study was to evaluate the association of dopaminergic gene variants with emotion dysregulation (EMD) and attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD). Three dopamine transporter gene (SLC6A3/DAT1) polymorphisms (intron8 5/6 VNTR, 3′-UTR 9/10 VNTR, rs27072 in the 3′-UTR) and one dopamine D2 receptor gene (DRD2) variant (rs2283265) were selected for genotyping based on à priori evidence of regulatory activity or, in the case of DAT1 9/10 VNTR, commonly reported associations with ADHD. A sample of 110 children with ASD was assessed with a rigorously validated DSM-IV-referenced rating scale. Global EMD severity (parents’ ratings) was associated with DAT1 intron8 (ηp2 = .063) and rs2283265 (ηp2 = .044). Findings for DAT1 intron8 were also significant for two EMD subscales, generalized anxiety (ηp2 = .065) and depression (ηp2 = .059), and for DRD2 rs2283265, depression (ηp2 = .053). DRD2 rs2283265 was associated with teachers’ global ratings of ADHD (ηp2 = .052). DAT1 intron8 was associated with parent-rated hyperactivity (ηp2 = .045) and both DAT1 9/10 VNTR (ηp2 = .105) and DRD2 rs2283265 (ηp2 = .069) were associated with teacher-rated inattention. These findings suggest that dopaminergic gene polymorphisms may modulate EMD and ADHD symptoms in children with ASD but require replication with larger independent samples. |
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| Keywords: | Autism Autism spectrum disorder Depression Emotion dysregulation ADHD DAT1 DRD2 |
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