低剂量γ射线辐照对血清抗氧化系统的兴奋效应 |
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引用本文: | 夏爱军,张献清,穆士杰,易静,吴原茹. 低剂量γ射线辐照对血清抗氧化系统的兴奋效应[J]. 西北国防医学杂志, 2009, 30(2): 100-102 |
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作者姓名: | 夏爱军 张献清 穆士杰 易静 吴原茹 |
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作者单位: | 第四军医大学西京医院输血科,陕西,西安,710032 |
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摘 要: | 目的:探讨低剂量γ射线辐照人全血对血清抗氧化酶活性的影响。方法:20份人全血,以剂量为1Gy的γ射线进行辐照,吸收剂量率为17Gy/min,分别于照射前及照射后1、2h取样检测血清中总抗氧化能力(T—AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH—Px)、过氧化氢酶(CAT)、谷胱甘肽还原酶(GR)活力及还原性谷胱甘肽(GSH)、丙二醛(MDA)含量。结果:离体全血在剂量为1Gy γ射线照射后1h,可见血清中GSH含量升高,MDA含量降低及T—AOC、SOD、GR、GSH—Px、CAT活性升高,且均与照射前比较有显著差异(P〈0.01)。经γ射线照射2h后,除SOD活性与照射后1h差异无显著性外,MDA含量进一步降低,GSH含量及T—AOC、GR、GSH—Px及CAT活性进一步升高,与照射后1h比较有显著差异(P〈0.01)。结论:低剂量γ射线辐照能明显提高血清抗氧化能力,即可诱导抗氧化系统的兴奋效应。
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关 键 词: | γ射线 抗氧化 照射 兴奋效应 |
Hormesis effect of serum antioxidative system after low dose human whole blood gamma ray irradiation |
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Affiliation: | XIA Ai - jun, ZHANG Xian - qing, MU Shi - jie, et al. ( Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, PLA, Xi'an 710032, China) |
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Abstract: | Objective:To investigate the activities of serum anti - oxidative enzymes by human whole blood gamma ray irradiation . Methods: Twenty units of human whold blood were irradiated by γ- ray at a dose of 1Gy. The absorption dose rate was 17 Gy/min. The serum enzymatic activities of total antioxidative capacity(T-AOC), superoxide dismutase ( SOD ), glutathione peroxidase ( GSH - Px ), catalase ( CAT), glutathionereductase ( GR ), contents of glutathione ( GSH ) and malondiadehyde ( MDA ) were deteted before and 1,2 h after irradiation respectively. Results: One hour after irradiation, the content of serum GSI-I was higher than that of pre - radiation (P 〈0.01 ). The content of serum MDA was lower than that of pre -radiation (p 〈 0.01 ). But the enzymatic activities of T - AOC, SOD, GSH - Px, GR and CAT were higher than that of pre - radiation (p 〈 0.01 ). In two hours after radiation group, the content of serum GSH was higher than that of one hour after radiation group (P 〈 0. 01 ), but content of serum MDA was lower(P 〈0.01 ). All antioxidative enzyme activities were higher than that of one hour after radiation group except SOD (p 〈 0.01 ). Conclusion: Gamma ray irradiation at low dose can obviously enhance the serum antioxidative abilities, that is to say, it results in the hormesis of antioxidation system. |
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Keywords: | Gamma ray Anti - oxidation Radiation Hormesis |
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