| 有丝分裂激酶Aurora-A活性调节的分子机制 |
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| 引用本文： | 王晓霞,樊飞跃,詹启敏.有丝分裂激酶Aurora-A活性调节的分子机制[J].医学分子生物学杂志,2005,2(6):436-439. |
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| 作者姓名： | 王晓霞 樊飞跃 詹启敏 |
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| 作者单位： | 中国医学科学院中国协和医科大学放射医学研究所,天津市,300192;中国医学科学院中国协和医科大学肿瘤研究所,北京市,100021 |
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| 基金项目： | 国家自然科学基金(No．30225018) |
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| 摘 要： | Aurora-A是一种参与有丝分裂的丝氨酸/苏氨酸激酶,其过表达与肿瘤形成有关。Aurora-A激酶活性可以通过磷酸化、去磷酸化以及依赖蛋白酶体的降解等方式进行调节。TPX2(target protein for Xenopus kinesin-like protein 2)、1-2(Inhibitor 2)、Ajuba通过磷酸化Aurora-A将其活化,PP1(type-1 proteinphosphatase)等通过去磷酸化Aurora-A而抑制其活性,而且APC／C-Cdh1依赖的蛋白酶体等可以将其降解。了解和认识Aumra-A激酶活性调节的分子机制将有助于理解它在有丝分裂及肿瘤形成中的作用。
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| 关 键 词： | 有丝分裂 Aurora-A 活性调节 |
| 修稿时间： | 2004年4月26日 |
Molecular Regulating Mechanism of Mitotic Aurora-A Kinase |
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| WANG Xiaoxia,FAN Feiyue,ZHAN Qimin.Molecular Regulating Mechanism of Mitotic Aurora-A Kinase[J].Journal of Medical Molecular Biology,2005,2(6):436-439. |
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| Authors: | WANG Xiaoxia FAN Feiyue ZHAN Qimin |
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| Institution: | WANG Xiaoxia~1,FAN Feiyue~1,ZHAN Qimin~2 ~1 institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300192,China ~2 Cancer Institute,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China |
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| Abstract: | Aurora-A has emerged as a new family of mitotic serine/threonine kinases.Overexpression of Aurora-A is associated with tumorigenesis.Aurora-A activity is regulated by phosphorylation, dephosphorylation and proteasome-dependent protein degradation pathways.TPX2, I-2 and Ajuba stimulate Aurora-A activity by binding and stimulating its phosphorylation.PP1 inhibits Aurora-A through dephosphorylation, and APC/C-Cdh1 can break down Aurora-A.Understanding of the mechanisms of the regulation of Aurora-A kinase at molecular level is helpful in the elucidation of its roles in mitosis and tumorigenesis. |
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| Keywords: | mitosis Aurora-A regulation of activity |
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