肝纤维化血清学诊断研究进展

肝纤维化是由各种慢性肝病引起细胞外基质在肝脏过度沉积所致,可进展为肝硬化并导致肝功能衰竭和门静脉高压等。肝纤维化具有可逆性已成为共识。因此,准确诊断和评估肝纤维化程度对肝纤维化的防治及其预后评估具有非常重要的意义。肝纤维化诊断的金标准是肝脏活检,但由于其具有创伤性、费用昂贵而难以被患者接受。血清学检查是诊断肝纤维化较为理想的检测方法,可对肝纤维化进行早期诊断,并可进行动态观察。由多个血清学指标组成的非创伤性诊断模型,提高了肝纤维化的诊断准确性。本文就肝纤维化的血清学诊断研究进展进行综述。

Advances in Serum Diagnosis of Liver Fibrosis

Liver fibrosis is hepatic excessive accumulation of extracellular matrix proteins including collagens occurring in various chronic liver diseases.It can progress to cirrhosis,resulting in liver failure and portal hypertension.There is a consensus that liver fibrosis is reversible,hence,definite diagnosis and estimating the degree of fibrosis are important for its prevention,treatment and prognostic assessment.Liver biopsy has long been taken as the gold standard for diagnosis of liver fibrosis.Yet it is invasive and not usually acceptable by the patients.Serum-based test is a non-invasive procedure,not only can it be used for its early diagnosis,but also for dynamic follow-up study.This diagnostic test consists of several serum-markers of liver fibrosis,which increases the diagnostic accuracy of liver fibrosis.Here the advances in the field of development and research study of serum diagnosis of liver fibrosis are reviewed.