地高辛给药方案与血药浓度及临床疗效的关系

目的:探讨地高辛给药方案对血药浓度及临床疗效之间的关系。方法:采用荧光偏振免疫法测定643例地高辛血药浓度,分析不同给药方案对血药浓度及疗效的影响。结果:不同给药方案组的血药浓度差异较大,临床疗效显示,无效45例,有效505例,中毒93例。有效血药浓度与中毒血药浓度之间存在一定程度的重叠,以0.125 mg/d时血药浓度达有效治疗浓度范围比例最高(93.02%),中毒发生率相对较低(4.07%)。结论:地高辛给药方案与血药浓度及临床疗效之间有很大的个体差异,影响因素较多,及时进行血药浓度监测,调整给药方案,才能保证治疗安全、有效。

Relationship between Dosage Regimen of Digoxin and Its Blood Concentration

Objectives: To investigate the dosage regimen of Digoxin with relation to its blood concentration and therapeutic effect.Method: The blood concentration of Digoxin in 643 patients was determined by fluorescent polarization immunoassay to analyze the effect of various dosage regimens on blood concentration and therapeutic effect.Results: The serum concentration of Digoxin was evidently different in different dosage regimens.And clinically,no response was shown in 45 patients;response was obtained in 505 cases;Digoxin poisoning was found in 93 patients.There existed a certain overlapping between the effective serum concentration and toxic blood concentration,indicating 0.125 mg/d would produce the highest effective serum concentration(93.02%) and the lowest poisoning(4.07%).Conclusion: There was a greatly individualized difference between dosage regimen and the serum concentration of Digoxin as well as the clinic therapeutic effect,which were affected by various factors.Therefore,timely monitoring the serum concentration and adjusting the dosage regimen could ensure a safe and effective treatment.