血液灌流抢救重度急性有机磷中毒的疗效观察

目的：探讨血液灌流（HP）抢救重度急性有机磷农药中毒（AOPP）的疗效及影响因素。方法：将64例重度AOPP病人随机分为观察组和对照组各32例，观察组在常规治疗基础上行血流灌流治疗，对照组按常规治疗，观察两组病人的治疗效果。结果：观察组清醒时间和达阿托品化的时间缩短，血清胆碱脂酶（ChE)恢复活力时间明显较对照组缩短（P＜0．05）；阿托品用量较对照组减少1／3（P＜0．05）；观察组痊愈27例，自动出院5例，痊愈率与对照组比较，差异有显著性意义（P＜0．05）。结论：重度AOPP病人在常规治疗的同时，早期给予HP治疗可提高抢救成功率。

Observation on the Therapeutic Effects of Hemoperfusion in the Emerge ncy Treatment of Severe Organophosphorous Insecticides Poisoning

Objective To investigate the therapeutic effects of hemoperfusion (HP) in the emergency treatment of severe acute organophosphorous pesticides poisoning and the factors influencing prognosis. Methods Sixty four cases of severe acute organophosphorous pesticides poisoning in hospital were randomly divided into two groups: observation group ( n =32) received HP treatment with routine treatment, control group ( n =32) received routine treatment. Results The time of regaining consciousness in the observation group was shortened. The time of reaching atropinization was reduced. The recovery time of choline esterase in the observation group was significantly shorter than in the control group ( P <0.05). The dose of atropine in the observation group was one third less than in the control group. In the observation group, 27 patients were fully recovered, 5 case left hospital voluntarily with the difference being significant between the two groups ( P <0.05). Conclusion HP treatment combined with routine treatment might enhance the rescuing rate for severe acute organophosphorous pesticides poisoners at the early stage.