Inhibitory activity of Chinese herbal medicines toward histamine release from mast cells and nitric oxide production by macrophage-like cell line, RAW 264.7 |
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| Authors: | Jue Wang Naili Wang Xinsheng Yao Rie Ishii Susumu Kitanaka |
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| Affiliation: | (1) College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan;(2) Life Science Division, Graduate School at Shenzhen, Tsinghua University, Tsinghua Campus, Shenzhen, 518055, China;(3) Institute of TCM and Natural Products, Jinan University, Shipai, Guangzhou, 510632, China;(4) Saitama Institute of Public Health, 639-1 Kamiokubo, Urawa, Saitama 338-0824, Japan |
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| Abstract: | One hundred and six species of traditional Chinese herbs were collected from the northeast of China, extracted with 60% ethanol, and tested for activity inhibiting histamine release and nitric oxide (NO) production. We found that 18 of the 106 species showed strong histamine-release inhibitory activity (inhibition >80%, 100  g/ml), of which Bidens parviflora Willd. was recognized to present the strongest activity (inhibition 97.8%, 100 g/ml). Seven species exhibited strong NO-production inhibitory activity (inhibition >50%, 100 g/ml) with Pholidota chinensis Lindl. as the most active one (inhibition 86.2%, 100 g/ml). |
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| Keywords: | Chinese herbs Histamine Nitric oxide Macrophage RAW 264.7 |
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