Pharmacological properties of 1-(4-methoxybutylamino)-2-(1-4-benzodioxan-2-yl)-ethane (2802 IS) |
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Authors: | V. G. Longo V. Rosnati |
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Affiliation: | (1) Laboratori di Chimica Terapeutica, Istituto Superiore di Sanità, Rome, Italy |
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Abstract: | Summary The pharmacological properties of 1-(4-methoxybutylamino)-2-hydroxy-2-(1,4-benzodioxan-2-yl) ethane (2802 IS) are described. 2802 IS when administered by vein to anesthetized dogs and cats in doses of 0.025-0.05 mg/kg lowered the blood pressure. In an instrumental reward discrimination exercise in rabbits the depressant effects of the compound were demonstrated at 0.25-0.5 mg/kg i.v. 2802 IS provokes significant changes of the cortical and subcortical electrical activity of the unanaesthesized rabbit and a dampening of the arterial pressure response to the electrical stimulation of the hypothalamus. The site of action of the central effect of the compound is discussed.This work has been supported in part by a Grant from the National Institute of Mental Health, U.S.A. (MH-07093). |
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