血清肝纤维化指标在肝病中的临床分析

目的:探讨联合检测Ⅲ型前胶原的氨基末端前肽(PⅢNP)、Ⅳ型胶原(CIV)、血清透明质酸(HA)、层粘蛋白(LN)对肝纤维化的诊断意义。方法:采用放射免疫分析法检测69例肝病患者的PⅢNP、CIV、LN、HA,同时与20例健康体检者比较。结果:四项血清肝纤维化标志物与慢性肝炎病情严重程度相关,在慢性肝炎重型组和肝硬化组中表达最高,以PⅢNP和HA升高最为显著。结论:PⅢNP、CIV、LN、HA联合检测对诊断肝纤维化有较高的临床价值,但不能用慢性肝炎重型和肝硬化的鉴别。

Clinical Analysis of Serum Hepatofibrosis Indices in the Patients with Hepatic Disease

Objective:To investigate the significance of combined testing aminoterminal propeptide of type III precollagen(PIIINP),collagen type IV(CIV),hyaluronic acid(HA) and laminin(LN) in the diagnosis of hepatofibrosis.Methods:Serum PIIINP,CIV,LN and HA of 69 patients with hepatic disease were examined by radioimmunoassay.The results were compared with those of 20 healthy persons.Results:Four serum indices on hepatofibrosis relate to the severity of the chronic hepatic disease.The highest serum indice levels were found in serious chronic hepatitis group and hepatic fibrosis group,and the increase of PIIINP and HA was most remarkable.Conclusion: Combined testing PIIINP,CIV,HA and LN is helpful for clinical diagnosis of hepatofibrosis,but the four serum indices can't be used in differentiating serious chronic hepatitis and hepatic fibrosis.