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| 尼莫同对严重烫伤幼年大鼠脑内水通道蛋白4表达的影响 | |
| 引用本文： | 胡维晟,刘曾旭,郭涌泉. 尼莫同对严重烫伤幼年大鼠脑内水通道蛋白4表达的影响[J]. 四川解剖学杂志, 2009, 17(2): 5-7 |
| 作者姓名： | 胡维晟 刘曾旭 郭涌泉 |
| 作者单位： | 1. 南昌大学医学院研究生部 2. 南昌大学医学院解剖学教研室,江西南昌,330006 3. 江西省万安县人民医院检验科,江西万安,343800 |
| 摘 要： | 目的探讨幼年大鼠严重烫伤后脑内水通道蛋白4（AQP4）的表达和脑含水量变化的影响。方法75只健康Wistar幼年大鼠随机分为烫伤组、尼莫同组和假烫伤组，每组25只。建立严重烫伤模型，所有实验大鼠分别在烫伤后2h、6h、12h、24h、48h断头处死后取脑．测定脑含水量，并用免疫组化测定AQP4的表达。结果烫伤组脑含水量及AQP4表达在2h后开始增高，6h后达高峰，尼莫同组与烫伤组和假烫伤组比较，各时间点脑含水量明显降低（P〈0．05）。结论AQP4与脑水肿形成有关，尼莫同可以降低脑组织内AQP4的表达．从而减轻脑水肿。 |
| 关 键 词： | 烫伤 脑水肿 AQP4 尼莫同 |
Effects of Nimotop on the Expression of AQP4 in the Severe Scald Young Rats'' Brain |
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| HU Wei-sheng,LIU Zeng-xu,GUO Yong-quan. Effects of Nimotop on the Expression of AQP4 in the Severe Scald Young Rats'' Brain[J]. Sichuan Journal of Anatomy, 2009, 17(2): 5-7 | |
| Authors: | HU Wei-sheng LIU Zeng-xu GUO Yong-quan |
| Affiliation: | 1.Grade 2006;Department of Postgraduate;Medical College of Nanchang University;2.Department of Anatomy;Nanchang 330006;3.Department of Laboratory;People' Hospital of Wanan;Wanan 343800 |
| Abstract: | Objective To study effects of Nimotop on the expression of AQP4 in the severe scald young rats' brain and their brian water content.Methods 75 normal young Wistar rats were randomized into false scald group,scald group and Nimotop group(each including 25 rats),The brain water content was detected and the expression of AQP4 were determined by immunohistochemical method after establishing the severe scald model at 2 h,6 h,12 h,24 h and 48 h.Results The brain water content and AQP4 expression of rats in severe... |
| Keywords: | AQP4 |
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