海洛因依赖者的海马区磁共振氢质子波谱改变

目的探讨海洛因依赖者的海马区氢质子磁共振波谱(1H MRS)改变。方法对30例自愿戒毒的海洛因依赖者及20例正常对照组进行脑部常规MR I及海马区1H MRS检查,分析海洛因依赖者海马区1H MR I波谱的改变。结果常规MR I扫描,所有检查者海马区均未见异常信号1。H MRS发现海洛因依赖者双侧海马区NAA/Cr低于正常对照组,有显著性差异(P<0.05);Cho/Cr与正常对照组比较无显著性差异。结论1H MRS可以早期显示海洛因的毒性效应造成的海马区神经元功能受损,而此时可不出现形态学改变。

1H MR Spectroscopy of Hippocampus in the Heroin -dependent Patients

Objective To study the~1H MR spectroscopy(~1H MRS) changes of hippocampus in the heroin-dependent patients.Methods Conventional MR scanning and~1H MRS were performed in 30 heroin-dependent patients and 20 normal controls.The changes of conventional MRI and~1H MRS of the hippocampus were analyzed.Results No abnormal signal was found at the hippocampus on conventional MR scanning.~1H MRS of hippocampus revealed the decrease of NAA/Cr ratio in the heroin-dependent patients,which was significant difference in comparison with the normal controls(P<0.05),but the Cho/Cr ratio had no significant difference between this two groups.Conclusion ~1H MRS can reveal the early damage of the neuronal function of hippocampus in heroin-dependent patients,but without the morphologic changes being found.