Streptozotocin diabetes in rats after acclimation to cold environment |
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| Authors: | T Takano T Honma Y Motohashi Y Kobayashi |
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| Institution: | 1. Department of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People''s Hospital, Changzhou, Jiangsu, 213003, China;2. The First Clinical School of Nanjing Medical University, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, 210029, China;3. Department of Nutrition, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People''s Hospital, Changzhou, Jiangsu, 213003, China;4. Department of Orthopedic, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China;1. Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;2. Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia;3. Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia;4. School of Medicine, University of Queensland, Brisbane, Queensland, Australia;5. Childrens Hospital Westmead, Sydney, New South Wales, Australia;6. University Francois Rabelais, Tours, France;7. Department of Nephrology and Clinical Immunology, Tours Hospital, Tours, France;8. INSERM, U1153, Paris, France;9. St. Vincent’s Hospital, Sydney, New South Wales, Australia;10. Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;11. Division of Cardiology, Department of Medicine, Hennepin County Medical Center/University of Minnesota, Minneapolis, Minnesota;12. Program in Health Services & Systems Research, Duke-NUS Graduate Medical School, Singapore;13. Department of Community Health Science, Aga Khan University, Karachi, Pakistan;14. Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan;15. The George Institute for Global Health, Sydney, New South Wales, Australia;p. Division of Nephrology, Department of Internal Medicine and Comprehensive Heart Failure Centre, University Hospital of Würzburg, Würzburg, Germany;q. Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada;r. BC Provincial Renal Agency, Vancouver, British Columbia, Canada;s. Centre for Health Evaluation and Outcomes Research, St. Paul’s Hospital, Vancouver, British Columbia, Canada;t. Department of Nephrology, Dialysistherapy and Internal Medicine, Warsaw Medical University, Warsaw, Poland;u. Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina;v. Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy;w. Medical Scientific Office, Diaverum, Lund, Sweden;x. Diaverum Academy, Bari, Italy;y. Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada;z. Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China;11. Renal Division, University Hospital of Würzburg, Würzburg, Germany;22. Inserm Clinical Investigation Center 1403, Université de Lorraine, CHU de Nancy, Nancy, France;33. Institut Lorrain du Coeur et des Vaisseaux CHU and Université de Lorraine, Nancy, France;44. Selzman Institute for Kidney Health, Section of Nephrology, Baylor College of Medicine, Houston, Texas;55. University College London, London, United Kingdom;3. Laboratories of Structural Sciences and Structural Biology and Biochemistry, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503;4. VARI-SIMM Center, Center for Structure and Function of Drug Targets, The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China;5. Department of Molecular Medicine, Translational Research Institute, The Scripps Research Institute, Jupiter, Florida 33458;6. The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom;1. Department of Medicine, Indiana University, Indianapolis, IN, USA;2. School of Public Health, Indiana University, Bloomington, IN, USA;3. Biocomplexity Institute, Indiana University, Bloomington, IN, USA;4. Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA;1. Protein Chemistry & Metabolism Unit, St Vincent''s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia;2. Immunology and Diabetes Unit, St Vincent''s Institute of Medical Research, 41 Victoria Parade, Fitzroy, VIC 3065, Australia;3. Cancer Therapeutics CRC Pty Ltd, Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia;4. Mercury Therapeutics Inc., 175 East New Boston Street, Woburn, MA 01801, USA;5. Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada |
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| Abstract: | To investigate the effects of acclimation to a cold environment on the alteration of glucose and fat metabolism in diabetes, the levels of blood glucose, triacylglycerol, nonesterified fatty acid, and immunoreactive insulin were measured before and on the 3rd and 14th days after streptozotocin treatment in cold-acclimated (4 degrees C) and warm-acclimated (24 degrees C; control) rats. The cold-acclimated rats showed no hyperglycemia on the 14th day after streptozotocin treatment, whereas the control diabetic rats maintained high blood glucose levels. Triacylglycerol levels did not increase in the cold-acclimated diabetic rats, whereas the control diabetic rats showed markedly high triacylglycerol levels. Immunoreactive insulin levels remained constantly low in both cold-acclimated and control diabetic rats. It was concluded that acclimation to cold changed some of the metabolic consequences of diabetes caused by streptozotocin in rats. |
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