| 免疫清除期慢性乙型肝炎患者外周血T细胞程序性坏死因子-1表达及其意义 |
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| 引用本文： | 李成忠,张迁,薛建亚,梁雪松. 免疫清除期慢性乙型肝炎患者外周血T细胞程序性坏死因子-1表达及其意义[J]. 肝脏, 2011, 16(4): 305-307,347 |
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| 作者姓名： | 李成忠 张迁 薛建亚 梁雪松 |
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| 作者单位： | 200433,上海长海医院感染科 |
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| 基金项目： | 上海市卫生局基金，中国肝炎基金会“光辉基金” |
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| 摘 要： | 目的 明确程度性坏死因子（PD-1）在免疫清除期慢性乙型肝炎患者外周血T细胞表达状态及其对患者病毒载量水平和生化指标的影响.方法 45例ALT升高的慢性乙型肝炎患者被纳入本研究.应用流式细胞术对所有患者的外周血总CD8+T细胞和CD4+T细胞PD-1表达百分比和表达强度进行检测,其中18例患者接受肝组织活检,并应用免疫...
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| 关 键 词： | 程序性坏死因子-1 慢性乙型肝炎 免疫清除期 乙型肝炎病毒 |
Expression and significance of programmed death 1 in T cell in peripheral blood of patients with chronic hepatitis B during the immune clearance phase |
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| LI Cheng-zhong,ZHANG Qian,XUE Jian-ya,LIANG Xue-song. Expression and significance of programmed death 1 in T cell in peripheral blood of patients with chronic hepatitis B during the immune clearance phase[J]. Chinese Hepatology, 2011, 16(4): 305-307,347 |
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| Authors: | LI Cheng-zhong ZHANG Qian XUE Jian-ya LIANG Xue-song |
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| Affiliation: | LI Cheng-zhong,ZHANG Qian,XUE Jian-ya,LIANG Xue-song.Department of Infectious Diseases,Changhai Hospital,Second Military Medical University,Shanghai,200433,China |
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| Abstract: | Objective To test feature of PD-1 expression and the effect of PD-1 expression on viral load and biochemical feature of chronic hepatitis B(CHB) patients in immune clearance phase.Methods Forty-five CHB with increased ALT were enrolled.PD-1 expression in total peripheral CD8+ and CD4+ T cell were evaluated by flow cytometry.Immunostaining was performed according to the EnVision ChemMate methods to determine PD-L1 expression.Results It was found that in CHB patients in immune clearance phase the percentage o... |
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| Keywords: | Programmed Death 1(PD-1) Chronic hepatitis B Immune clearance phase |
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