苯磺酸左旋氨氯地平联合赖诺普利对原发性高血压患者尿微量白蛋白的影响

目的探讨苯磺酸左旋氨氯地平联合赖诺普利对高血压患者尿微量白蛋白的影响。方法将60例高血压患者随机分为左旋氨氯地平组(2.5⁵ mg/d),赖诺普利组(105 mg/d),赖诺普利组(10²0 mg/d)和联合治疗组(氨氯地平2.5 mg/d联合赖诺普利10 mg/d),3组于治疗前和治疗后4、10、20周检测尿微量白蛋白,血清肌酐及尿素氮水平。结果 3组患者治疗后收缩压及舒张压水平较治疗前均有明显下降,差异有统计学意义(P<0.05)。3组治疗4周后,尿微量白蛋白都有所下降,联合治疗组更明显。3组血清肌酐,尿素氮水平较前无明显变化(P>0.05)。结论苯磺酸左旋氨氯地平联合赖诺普利降压效果明显,可减少高血压患者尿微量白蛋白。

The Impact of Levamlodipine Combined with Lisinopril on Urine Microalbuminuria in Patients with Essential Hypertension

Objective To discuss the effect of levamlodipine and lisinopril tablets in patients with essential hypertension and the impact of urine microalbuminuria. Methods 60 cases of essential hypertension with microalbuminuria, according to the order of treatment were randomly divided into 3 groups： oral levamlodipine 2.5-5 mg/d; oral Lisinopril 10-20 mg/d; oral Levamlodipine 2.5 mg/d＋lisinopril 10 mg/d. Comparing pretherapy with posttreatment 4 weeks, 10 weeks, 20 weeks in decreasing blood pressure levels of three treatment groups. Microalburn inuria, serum nitrogen and creatinine were examined at the same time. Results Both SBP and DBP were significantly decreased in there groups after 20 weeks（P〈0.05）. After 4-week treatment, microalbuminuria was decreased in three groups, especially in the combined group. And there were no statistical significance on the level of serum nitrogen and creatinine. Conclusion The levamlodipine with lisinopril are more effective in lowering blood pressure and decreasing microalburninuria.