PGⅠ、PGⅡ的水平在胃癌诊断中的意义

目的探讨血清中胃蛋白酶原(PGⅠ、PGⅡ)含量及其比值(PGR),在胃癌诊断中的意义。方法采用时间分辨荧光免疫分析法(TRFIA),检测198例正常对照者、89例胃溃疡患者及67例胃癌患者血清中的PGⅠ、PGⅡ含量并计算PGR。结果胃溃疡患者PGⅠ、PGⅡ较正常对照组明显升高,差异具有显著性(P<0.05),PGR差异无显著性(P>0.05);胃癌患者PGⅠ、PGR较正常对照组显著降低,差异显著(P<0.01),PGⅡ差异无显著性(P>0.05)。结论测定血清PGⅠ、PGⅡ水平及PGR值对胃癌的早期筛查及鉴别诊断有临床意义。

PG I and PG Ⅱ Levels for the Gastric Cancer Diagnosis Significance

Objective The objective of this study was to explore the significance of serum pepsinogen I and Ⅱ （PG I, PG Ⅱ ） content and its ratio （PGR） in the diagnosis of gastric cancer. Methods We use time-resolved fluorescence immunoassay （TRFIA） to test serum pepsinogen I and Ⅱ （PG I, PG II ） content and its ratio （PGR） in 198 cases of normal controls, 89 patients with gastric ulcer and 89 cases of gastric cancer patients. Results The content of PG I, PG Ⅱ in Patients with gastric ulcer was obviously higher than normal control group, with significant difference （P〈0.05）, PGR had no significant difference （P〉0.05）; PG I, PGR in gastric cancer patients significantly reduced compared with normal control group, with significant difference （P〈0.01）; PG Ⅱ had no significant difference （P〉0.05） between the two groups. Conclusion We conclude that serum pepsinogen I and Ⅱ （PG I, PG Ⅱ ） contem and its ratio （PGR） in the diagnosis of gastric cancer has important clinical significance.