The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation |
| |
Authors: | Lin Yen-Hung Ho Yi-Lwun Wang Tzung-Dau Liu Chung-Pin Kao Hsien-Li Chao Chia-Lun Chien Kuo-Liong Hung Chi-Sheng Wu Vin-Cent Tsai I-Jung Yen Ruoh-Fang Shiau Yu-Chien Chen Wen-Jone |
| |
Affiliation: | Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan. |
| |
Abstract: | OBJECTIVES: The association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is unclear. We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients. DESIGN AND METHODS: Forty-six patients (32 men; mean age 64 years) with chest pain were enrolled. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the amino-terminal propeptide of type I and III procollagen (PINP and PIIINP). RESULTS: In patients with thallium-201 perfusion defects, the number of diseased vessels was associated significantly with PIIINP (p=0.024) rather than PINP (p=0.613). Follow-up serum PINP and PIIINP levels after coronary intervention (mean 84 days) revealed no significant decrease. CONCLUSIONS: Serum PIIINP level is significantly associated with the severity of CAD in patients without myocardial infarction or hibernation. |
| |
Keywords: | Coronary artery disease PINP PIIINP Myocardial fibrosis |
本文献已被 ScienceDirect PubMed 等数据库收录! |