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Effects of cyclosporin on serum hyaluronan levels in collagen arthritis |
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| Authors: | K. Takagishi M. Itoman Y. Goso S. Kuwao H. Miyahara N. Kaibara |
| Affiliation: | (1) Department of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228 Sagamihara, Kanagawa, Japan;(2) Department of Biochemistry, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228 Sagamihara, Kanagawa, Japan;(3) Department of Pathology, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228 Sagamihara, Kanagawa, Japan;(4) Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, 812 Fukuoka, Japan;(5) Kaibara Orthopedic Hospital, 8-20, Gion-machi, Hakata-ku, 812 Fukuoka, Japan |
| Abstract: | Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model. |
| Keywords: | Collagen Arthritis Cyclosporin and hyaluronan |
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