三株小鼠乳腺癌(Ca759, Ca761, Ca763)的肿瘤演进

观察了三株615系小鼠可移植性乳癌(Ca759、Ca761、Ca763)在建株和保种过程中肿瘤组织形态学与生物学行为方面的变化。分析比较肿瘤的演进过程,其共同特点为:瘤组织结构趋向简化,核分裂数增多,接种后肿瘤生长的潜伏期和宿主生存期缩短。但是这些变化发生的迟早、进展快慢及形态学表现等,在三个瘤株之间也有某些差异。Ca759自第1代至140代,Ca761自第1至79代,传代过程组织结构简化均呈渐进性。Ca763移植至第5代后肿瘤潜伏期与宿主存活期急剧缩短,组织学图象与原发瘤及第4代有显著差别。Ca761自80代以后宿主存活期突然缩短,瘤细胞核分裂数增多。三个瘤株演进的这些差异似乎表明在引起演进的机制上存在着差别,这是值得进一步探讨的问题。

PROGRESSION OF THREE TRANSPLANTABLE STRAINS OF MAMMARY CARCINOMA IN 615 INBRED MICE

Changes in histomorphology and biologic behavior during the course of the establishing and retaining of 3 transplantable strains of mammary carcinoma (Ca759, Ca761, Ca763) in syngenic 615 mice were observed. Through analysing and comparing the changes of these 3 tumor strains during successive passages, it was found that the common features of tumor Progression were: tending to become simplified in histological structure,increased in the number of mitosis, and shortening of both the latent period of tumor growth and the survival time of hosts. But there were some differences in the time of occurrence, the rapidity and the histological appearance of progression among Ca759, Ca761 and Ca763. In Ca759 through 140 transplant passages, and in Ca761 through 79 transplant passages, simplification of histologic structures progressively developed, while in Ca763, after 5 transplant passages the latent period of tumor growth and the survival time of the hosts were shortened abruptly, and its histologic patterns were conspicuously different from those of the primary and the 4th generation of tumor transplantation. In Ca761, since the 80th generation onwards, the survival time of the hosts were shortened abruptly, and also the mitotic number of tumor cells was increased. The differences of tumor progression among these 3 transplantable tumor strains appear to suggest that the mechanisms involved in the progression of these 3 tumor strains were somewhat different, and it was appreciable to investigate this problem further.