膀胱癌组织中蛋白激酶C的表达

目的　探讨蛋白激酶C(PKC)在膀胱癌发病机制中的作用及其意义。方法　应用免疫组化方法检测 82 例膀胱癌组织和12例正常膀胱组织中PKC和增殖细胞核抗原(PCNA)的表达。结果　膀胱癌组织中PKC阳性率为56.1%,显著高于正常膀胱组织的25.0%(P<0.05)。PKC表达与肿瘤分级、分期无显著相关性,复发者 PKC表达显著高于无复发者。膀胱癌 PKC阳性表达者的PCNA指数显著高于阴性表达者。结论　PKC异常表达促使细胞过度增殖,进而参与膀胱癌发病过程的调控。

Expression of protein kinase C in bladder cancer

Objective To investigate the role of protein kinase C (PKC) in pathogenesis of bladder cancer and its clinical signicance. Methods Immunohistochemistry methods were adopted to examine expressions of PKC and proliferating cell nuclear antigen (PCNA) in 82 cases with bladder cancer and 12 cases with normal bladder tissue. Results In bladder cancer, the positive expression rate of PKC was 56.1%, which was significantly higher than the rate in normal bladder tissue, which was only 25.0%(P< 0.05). The PKC expression was not significantly associated with tumor grade or stage, but higher expression was found in tumor recurrence cases than in non-recurrence cases. PCNA index was higher in PKC positive expression of bladder cancer than in PKC negative expression. Conclusion Abnormal expression of PKC is involved in the development and progression of bladder cancer by promoting cell proliferation.