依那普利对充血性心力衰竭患者血循环内皮细胞及脑钠素的影响

目的探讨充血性心力衰竭(CHF)时血循环内皮细胞(CEC)计数、血浆脑钠素(BNP)、血浆内皮素(ET-1)及6酮前列腺素F1α(6-Keto-PGF1α)水平的变化及依那普利的干预效应。方法25例CHF患者服用依那普利2周,并检测用药前后自身外周血循环CEC数量、血浆ET-1、BNP及6-Keto-PGF1α的含量,20名健康体检者为对照组。结果CHF患者CEC数量、血浆ET-1及BNP水平明显增高。6-Keto-PGF1α明显减少(P<0.01)。依那普利治疗可使CEC数量、血浆ET-1及BNP水平明显降低及6-Keto-PGF1α含量明显增加(P<0.01)。结论心力衰竭时存在血管内皮细胞受损,而依那普利具有保护血管内皮细胞及改善心功能的作用。

Effects of enaprili on circulation endothelial cells and plasmas brain natriuretic peptide in patients with congestive heart failure

Objective To investigate the effects of enaprili on the numbers of circulation endothelial cells(CEC),plasma brain natriuretic peptide(BNP),endothelin-1 and 6-Keto-plostagkndin F_(1α)(6-Keto-PGF_(1α)) cells in patients with congestive heart failure(CHF).Methods CEC counting,plasma BNP,ET-1 and 6-Keto-PGF_(1a) concent rations were detected before and after two weeks of oral treatment with enaprili in 25 patients with CHF.Results The numbers of CEC,the contents of plasma BNP and ET-1 were significantly increased and content of 6-Keto-PGF_(1α) was markedly decreased in patients with CHF (P<0.01).A significantly decreased CEC counting,plasma BNP and ET-1 contents and increased 6-Keto-PGF_(1α) level were observed after two weeks of enaprili therapy (P<0.01).Conclusion The structure and function of vascular endothelial cells are damaged in patients with CHF and enaprili has a beneficial effect on vascular endothelial cells.