| 胰岛素样生长因子-1的神经保护作用 |
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| 引用本文： | 韩彩萍,胡长林. 胰岛素样生长因子-1的神经保护作用[J]. 国际脑血管病杂志, 2005, 13(1): 46-49 |
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| 作者姓名： | 韩彩萍 胡长林 |
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| 作者单位： | 400010,重庆医科大学附属第二医院神经内科;400010,重庆医科大学附属第二医院神经内科 |
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| 摘 要： | 胰岛素样生长因子- 1(IGF- 1)是一种多肽类神经营养因子。在生理条件下,IGF- 1及其受体广泛分布于中枢神经系统;在病理条件下,IGF -1表达上调,并通过促分裂原活化蛋白激酶和磷脂酰肌醇3 激酶/丝氨酸-苏氨酸蛋白激酶等信号通路,抑制细胞凋亡、调节离子通道活性、抑制一氧化氮毒性等多种途径发挥神经保护作用。
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| 关 键 词： | 胰岛素生长因子-1 促分裂原活化蛋白激酶 磷脂酰肌醇3-激酶 神经保护 |
| 修稿时间： | 2004-11-10 |
The Neuroprotective Effects of Insulin-Like Growth Factor-1 |
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| Cai-Ping Hah,Chang-Lin Hu. The Neuroprotective Effects of Insulin-Like Growth Factor-1[J]. International Journal of Cerebrovascular Diseases, 2005, 13(1): 46-49 |
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| Authors: | Cai-Ping Hah Chang-Lin Hu |
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| Abstract: | Insulin-like growth factor-1 (IGF-1) is a polypeptide neurotrophic factor. Under the physiological condition, IGF-1 and its receptor are widely distributed in the central nervous system, and under the pathologic condition, the expression of IGF-1 is upregulated. IGF-1 inhibits cell apoptosis, regulates ion channel activity and inhibits the nitric oxide toxicity via mitogen-activated protein kinase and phosphatidyl inositol 3 kinase /serine-threonine protein kinase signaling pathways, thus exerts neuroprotective effects. |
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