肝癌患者P53蛋白表达及其临床病理意义

通过免疫组织化学ＳＰ法检测原发性肝癌患者癌及癌基因Ｐ５３蛋白的表达，揭示其与患者的临床病理改变之间的联系。结果Ｐ５３蛋白在肝癌及癌旁组织中的检出率分别为３０．４％和７．９％，定位于肝细胞的胞浆内，肝癌细胞的胞核内；Ｐ５３蛋白表达与癌细胞的分化存在着明显联系；而与癌块大小、肝内外转移和播散及患者的预后无关。本文提示抑癌基因的Ｐ５３的失活可能参与了肝癌的发生，但与其生物学行之间的联系不大。

Expression of p53 Protein in the Livers of Hepatocellular Carcinoma and its Clinical and Pathological Relationship

To detect the expression of p53 protein in the tissues of hepatocellular carcinoma with immunohistochemical SP method and elucidate its clinical and pathological relationship. It was found that the detection rates of p53 protein in the cancerous and peri-cancerous tissues were 30. 4 % and 7. 9 % (P <0. 05),respectively. p53 protein was locared in the cytoplasm of hepatocytes and nucleus of HCC cells. There was a significant relationship between the expression of p53 protein and the differentialion of HCC cells (P <0. 05),but no relationship with the diameter of cancerous mass, intrahepatic and extrahepatic metastases and the prognosis (P >0.05). It suggests the inactivation of p53 tumor suppressor gene could be associated with the development of HCC,but no obvious association with their biological behaviors.