| 乙醇对大鼠胃粘膜主细胞的损伤及丹参提取物F的保护作用研究 |
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| 引用本文： | 周平,李和泉,永田博司. 乙醇对大鼠胃粘膜主细胞的损伤及丹参提取物F的保护作用研究[J]. 中国中西医结合杂志, 1998, 0(Z1) |
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| 作者姓名： | 周平 李和泉 永田博司 |
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| 作者单位： | 锦州医学院病理生理教研室，中国医科大学病理生理教研室，日本国庆応义塾大学医学部济生会中央病院内科 辽宁121001 |
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| 基金项目： | 中日医学教育中心资助课题 |
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| 摘 要： | 目的:探讨乙醇对大鼠胃粘膜主细胞的损伤及丹参提取物 F 的保护作用。方法:本实验首先采用 Pronase-EDTA 法分离出大鼠胃粘膜主细胞,然后观察乙醇对细胞的损伤作用及丹参提取物 F 对其的影响。结果:乙醇可使胃粘膜主细胞生存率下降和乳酸脱氢酶漏出增加,二者呈显著的负相关关系;丹参提取物 F 可减轻乙醇诱发的细胞生存率下降及乳酸脱氢酶漏出增加。结论:丹参提取物 F 对乙醇诱发的胃粘膜主细胞损伤具有直接的细胞保护作用。
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| 关 键 词： | 胃粘膜主细胞 损伤 乙醇 丹参提取物 F |
Study on Ethanol-induced Injury to Isolated Gastric Chief Cells of Rats and the Protecting Effect of Radix Salviae Miltiorrhizae Extract-F on the Cells |
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| Zhou Ping Li Hequan Hiroshi Nagata Department o f Pathoph ysiology,Jinzhou Medical College,Liaoning. Study on Ethanol-induced Injury to Isolated Gastric Chief Cells of Rats and the Protecting Effect of Radix Salviae Miltiorrhizae Extract-F on the Cells[J]. Chinese journal of integrated traditional and Western medicine, 1998, 0(Z1) |
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| Authors: | Zhou Ping Li Hequan Hiroshi Nagata Department o f Pathoph ysiology Jinzhou Medical College Liaoning |
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| Abstract: | Objective:To study ethanol-induced injury to isolated gastric chief cells of rats and the protective effect of Radix Salviae Miltiorrhizae extract-F (RSME-F) on the cells.Methods:The chief cells of the gastric mucosa were separated with Pronase-EDTA method;then the ethanol-induced injury to the cells and the protective effect of RSME-F on the cells were studied.Results:Ethanol could cause a decline in cell survival rate,an increase in LDH release of gastric chief ceils, and a marked negative correlation between them.These changes caused by ethanol could be reduced by RSME-F.Conclu- sion:RSME-F has direct protective effect on the gastric with chief cells ethanol-induced injury. |
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| Keywords: | gastric chief cells injury ethanol Radix salviae Milliorrhizae extract-F |
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