Bone marrow and peripheral blood globin chain biosynthesis in iron deficiency |
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Authors: | M A Zago C Bottura |
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Institution: | (1) Division of Hematology and Cytology, Department of Clinical Medicine, School of Medicine, 14 100 Ribeirão Preto, Brazil |
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Abstract: | Summary Globin chain synthesis was studied in 13 iron-deficient patients. The mean whole-cell globin / ratio in the peripheral blood of 11 patients was 1.05±0.06 which is similar to the value 0.99±0.08 obtained for 10 controls. The ratios odtained for stroma-free globin were not significantly different from those of whole cell preparations. In contrast, the / ratio of bone marrow was 0.73±0.14 in 10 iron deficient patients, which is significantly lower than that of controls. Two other patients had decreased / ratios in the peripheral blood, probably because of the presence of an -thalassemia gene. These results demonstrate a reduced rate of synthesis of chains relative to that of chains in the bone marrow of iron-deficient patients that is not demonstrable in the peripheral blood.This work was partly supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil |
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Keywords: | Iron deficiency Globin synthesis -Thalassemia" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">-Thalassemia |
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