| 抑郁症患者脑脊液生长抑素及单胺代谢产物的测定 |
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| 引用本文： | 陈珏,张心保,侯钢.抑郁症患者脑脊液生长抑素及单胺代谢产物的测定[J].中华精神科杂志,1999,32(4):216-219. |
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| 作者姓名： | 陈珏 张心保 侯钢 |
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| 作者单位： | 南京医科大学附属脑科医院(陈珏!210029，张心保!210029，侯钢!210029，张石宁!210029，翟书涛!210029)，南京军区总医院(许瑞杰) |
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| 摘 要： | 目的 探讨抑郁症可能的生化病理机制，方法 采用放射免疫测定法及高效液相色谱法，分别测定２７例抑郁症患者和２７例对照者脑脊液（ＣＳＦ）生长抑素（ＳＳ）及单胺代谢产物水平。结果抑郁症组ＧＳＦ中ＳＳ水平和３－甲氧－４羟苯乙二醇（ＭＨＰＧ）水平（Ｐ〈０．０５）和５－羟吲哚乙酸水平（Ｐ〈０．０１），均低于对照组，而抑制症组ＣＳＦ中高香草酸含量与对照组间的差异无显著性（Ｐ〉０．０５）；抑郁症组ＣＳＦ中ＳＳ与Ｍ
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| 关 键 词： | 抑郁症 生长抑素 MHPG 脑脊液 |
Measurement of cerebrospinal fluid levels of somatostatin and monoamine metabolites in patients with depression |
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| CHEN Jue,ZHANG Xinbao,HOU Gang,et al.Measurement of cerebrospinal fluid levels of somatostatin and monoamine metabolites in patients with depression[J].Chinese Journal of Psychiatry,1999,32(4):216-219. |
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| Authors: | CHEN Jue ZHANG Xinbao HOU Gang |
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| Institution: | CHEN Jue,ZHANG Xinbao,HOU Gang,et al Department of Psychiatry,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029 |
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| Abstract: | Objective The aim of this study was to explore the possible pathophysiological mechanism in depression Methods Cerebrospinal fluid (CSF)somatostatin (SS) level was determined with radioimmunoassay, and CSF levels of monoamine metabolites were determined with high performance liquid chromatography in 27 patients with endogenous depression and 27 normal controls Results CSF levels of SS, 3 methoxy 4 hydroxyphenylglycol (MHPG) and 5 hydroxyindoleacetic acid were significantly lower in depressive group than in control group And in depressive group, a positive relationship was observed between CSF SS level and MHPG level ( r = 0 598, P< 0 01) CSF levels of both SS and MHPG in depression were significantly and negatively correlated with the depressive severity ( r= -0 479, P< 0 05; r= -0 434, P< 0 05) Conclusions Both monoamine neurotransmitters including serotonin (5 HT) and norepinephrine, and the neuropeptide SS might play important role in the pathophysiological mechanism of depression |
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| Keywords: | Depression Somatostatin 3 methoxy 4 hydroxyphenylglycol |
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