| 紫杉醇脂质体细胞毒作用和抗瘤作用的研究 |
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| 引用本文： | 卫凤英,成文彩.紫杉醇脂质体细胞毒作用和抗瘤作用的研究[J].华中科技大学学报(医学版),2001,30(1):46-49. |
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| 作者姓名： | 卫凤英 成文彩 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科, |
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| 基金项目： | 卫生部科研基金资助项目（No.
96-2-113） |
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| 摘 要： | 为研究紫杉醇脂质体的体外细胞毒作用及体内抗瘤作用。进行噻唑蓝（MTT）体外试验法和腹腔给药体内抗瘤试验。发现紫杉醇脂质体对体外培养的人卵巢癌细胞COC1在浓度为22.5μg/ml、45μg/ml和90μg/ml时，其抑制率分别为78.48%、84.90%和93.53%。体内腹腔给予紫杉醇脂质体5mg/(kg
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| 关 键 词： | 紫杉醇 脂质体 细胞毒作用 抗瘤作用 |
| 修稿时间： | 1999年12月28 |
Study on Cytotoxic Effect
and Antitumor Effect of Paclitaxel Liposome |
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| Wei Fengying,Cheng Wencai.Study on Cytotoxic Effect
and Antitumor Effect of Paclitaxel Liposome[J].Journal of Huazhong University of Science and Technology(Health Sciences),2001,30(1):46-49. |
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| Authors: | Wei Fengying Cheng Wencai |
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| Institution: | Wei Fengying,Cheng Wencai Department of Obstetrics and Gynecology,The Affiliated Tongji Hosptial,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | The cytotoxic effect and antitumor effect of paclitaxel liposome were studied by using MTT assay method in vitro and in vivo antitumor test. The inhibitory rate of paclitaxel liposome on human ovarian cancer cell COC1 was 78.48 %, 84.90 %, 93.53 % respectively at the concentrations of 22.5 μg/ml, 45 μg/ml, 90 μg/ml respectively. Under the doses of 5 mg/(kg*d) and 10 mg/(kg*d) for 8 days, the inhibitory rate of paclitaxel liposome against xenograft of solid Ehrlich tumor in mice was 32.47 % and 54.63 % respectively (P<0.01). The weight change rate of the mice was 22.11 % and 21.16 % respectively. It was suggested that paclitaxel liposome possessed in vitro and in vivo antitumor activities. The toxicity of liposomal paclitaxel was lower than that of free paclitaxel. |
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| Keywords: | paclitaxel liposome cytotoxic effect antitumor effect |
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