乙肝免疫球蛋白联合黄芪颗粒阻断乙肝病毒母婴传播的临床观察

目的:研究乙型肝炎病毒(HBV)携带孕妇应用乙肝免疫球蛋白(HBIG)联合中药黄芪颗粒对阻断乙肝母婴传播的效果。方法:140例患者随机分为3组。实验组50例,于孕28、32、36周分别注射HBIG 200IU,同时口服中药黄芪颗粒,每天30g,连服10天。对照组50例,于孕28、32、36周分别注射HBIG 200IU。空白组40例,仅常规产前检查及监护。结果:实验组较对照组、空白组新生儿出生时脐静脉血HBsAb阳性率显著升高(P0.05及P0.01),HBV-DNA(+)感染率显著下降(P0.01),结论:对HBV携带者孕晚期多次应用HBIG联合中药黄芪颗粒,能增强孕妇主被动免疫,提高阻断乙型肝炎病毒母婴垂直传播率。

Clinical Observation on Blocking Hepatitis B Virus MTCT by Hepatitis B Immunoglobulin Combined with Astragalus Granule

Objective：To study the effect of blocking the transmission of hepatitis B particles from mothers to children,with the application of hepatitis B immune globulin（HBIG） combined TCM Astragalus Granula in pregnant women who carry the hepatitis B surface antigen（HBsAg） and their newborns.Methods：The 50 patients of experimental group were injected HBIG 200 IU and accepted the oral administration of Astragalus particles lasting 10 days at a dose of 30 g/day,when they were 28,32 and 36 weeks in the pregnancy.The 50 patients of control group were injected HBIG 200 IU when they were 28,32 and 36 weeks in the pregnancy.The 40 patients of blank group were only given routine antenatal examination and monitoring.Results：The positive rate of HBsAb in the neonatal cord blood of newborn who were in the experimental group was obviously lower than the control group and blank group（P0.05 P0.01）,while the infection rate of HBV-DNA（＋） was significant reduced（P0.01）.Conclusion：It can block the vertical transmission of hepatitis B virus effectively in the late pregnancy HBV carriers who applied HBIG combine with traditional Chinese medicine Astragalus Granula on various occasions.