The antitumor effect of a novel nitrosourea, tauromustine, at intravenous administration in rat. Cure of hepatomas. |
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Authors: | G Roos I A el Hag P I Christensson U Stenram |
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Affiliation: | Department of Pathology, Lund University, University Hospital, Sweden. |
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Abstract: | The effect of intravenously injected tauromustine (TCNU) on tumor growth and body weight was studied in rats with subcutaneously implanted experimental carcinomas. With a colonic tumor, a single dose or that dose split on 4 consecutive days gave the same tumor growth delay but the body weight loss was less at the split dose. Injection of the single dose for 1 min, 30 min or 2 h each had the same effect. Rats of another strain were implanted with a hepatoma. 9 out of 10 rats were cured. A late effect was body weight loss due to disturbed growth of the teeth. |
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