Combination chemotherapy with cyclophosphamide,vincristine, procarbazine,and prednisone (COPP) in children with brain tumors |
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| Authors: | Lawrence J Ettinger Daven Sinniah Stuart E Siegel Lawrence S Fishman Hervey D Segall Daljit Soni Geni A Bennetts David H Schultz David Raphael |
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| Affiliation: | (1) Childrens Hospital of Los Angeles and the Department of Pediatrics, Division of Hematology-Oncology, USA;(2) Childrens Hospital of Los Angeles and the Department of Pediatrics, Division of Neurology, USA;(3) Department of Radiology, Childrens Hospital of Los Angeles and the Department of Radiology, University of Southern California, School of Medicine, Los Angeles, CA, USA;(4) Division of Radiation Oncology, Childrens Hospital of Los Angeles and the Department of Radiology, University of Southern California, School of Medicine, Los Angeles, CA, USA;(5) Department of Pediatrics, University of Malaya, Kuala Lumpur, Malaysia;(6) Department of Hematology-Oncology, Children's Hospital of Orange County, Orange, CA, USA;(7) Department of Pediatrics, University of California at Irvine, Irvine, CA;(8) Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, Academic Health Science Center CN 19, 08903 New Brunswick, NJ, USA |
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| Abstract: | Summary The chemotherapeutic combination of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) was used to treat 15 children with recurrent central nervous system tumors and seven children with newly diagnosed brainstem tumors. In patients with recurrent tumors, marginal activity was seen in various histologic types. COPP chemotherapy was clearly ineffective in patients with brainstem tumors. Toxicity consisted of mild to moderate myelosuppression and neurotoxicity. |
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| Keywords: | COPP chemotherapy brain tumors cyclophosphamide vincristine procarbazine |
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