Role of the quorum-sensing system in experimental pneumonia due to Pseudomonas aeruginosa in rats |
| |
| Authors: | Lesprit Philippe Faurisson Francois Join-Lambert Olivier Roudot-Thoraval Francoise Foglino Maryline Vissuzaine Christiane Carbon Claude |
| |
| Affiliation: | Service d'Immunologie Clinique, H?pital Henri Mondor, 51 avenue du Maréchal de Lattre, 94010 Créteil, France. phillipe.lesprit@hmn.ap-hop-paris.fr |
| |
| Abstract: | The virulence of Pseudomonas aeruginosa is partly controlled by the las quorum-sensing system. A rat model of acute pneumonia was used to investigate the pathophysiological impact of this system by comparing the virulence of the wild-type virulent laboratory strain PAO1 with that of its lasR-deleted mutant PAOR. In comparison with PAO1, PAOR was avirulent after an instillation of 106 cfu (mortality rates, 72 versus 0%, respectively; p < 0.0001). A ten-fold higher inoculum slightly increased the mortality rate induced by PAOR (25%), which remained lower than that induced by PAO1 (75%, p = 0.0001). In addition, with both inocula lung and bronchoalveolar lavage bacterial counts were significantly lower in rats infected with PAOR than with PAO1 (p
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
