| 克林霉素凝胶的制备及质量控制 |
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| 引用本文： | 徐晓,李国锋. 克林霉素凝胶的制备及质量控制[J]. 中国药房, 2005, 16(17): 1307-1308 |
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| 作者姓名： | 徐晓 李国锋 |
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| 作者单位： | 1. 广州市皮肤病防治所,广州市,510095
2. 南方医科大学临床药理研究所,广州市,510095 |
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| 摘 要： | 目的:制备克林霉素凝胶并建立其质量控制方法。方法:以盐酸克林霉素为主药,卡波姆-934、丙二醇等为辅料制备凝胶;采用高效液相色谱法测定盐酸克林霉素的含量。结果:所制凝胶质地均匀,粘稠度适中;盐酸克林霉素检测浓度线性范围为20～80μg/ml,平均回收率为99.50%,RSD=1.05%。结论:该制剂性质稳定,质量易控。
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| 关 键 词： | 克林霉素 凝胶 制备 质量控制 |
| 文章编号： | 1001-0408（2005）17-1307-02 |
| 收稿时间： | 2004-12-16 |
| 修稿时间： | 2005-01-25 |
Preparation and Quality Control of Clindamycin Gel |
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| XU Xiao,Li Guofeng. Preparation and Quality Control of Clindamycin Gel[J]. China Pharmacy, 2005, 16(17): 1307-1308 |
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| Authors: | XU Xiao Li Guofeng |
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| Abstract: | OBJECTIVE:To prepare clindamycin gel and to establish its quality control.METHODS:Hydrochloride clindamycin was used as the principal agent,carbomer-934,propylene glycol as preservatives to prepare clindamycin gel;HPLC method was adopted to determine the content of clindamycin.RESULTS:The prepared gel showed fine consistency and moderate viscosity;The detected concentration of clindamycin was linear in the range of20～80μg/ml,the average recovery rate was99.50%,RSD=1.05%.CONCLUSION:This preparation is stable in quality and the quality control is feasible and reliable. |
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| Keywords: | Clindamycin Gel Preparation Quality control |
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