| 卡托普利对冠状动脉急性闭塞后室性心律失常的影响 |
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| 引用本文： | 张福兴 阎西艴. 卡托普利对冠状动脉急性闭塞后室性心律失常的影响[J]. 河南医学研究, 1997, 6(3): 219-221 |
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| 作者姓名： | 张福兴 阎西艴 |
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| 作者单位： | [1]焦作市人民医院心内科 [2]河南医科大学第一附属医院心内科 |
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| 摘 要： | 目的:研究卡托普利(Captopril)对室性心律失常的治疗作用及其可能机制。方法:对17只兔心脏(对照组 n=8;干预组 n=9)行冠状动脉左室支中点完全结扎120分钟,观察两组心室纤颤(VF)发生率、心肌缺血面积、血浆去甲肾上腺素(NE)和血管紧张素Ⅱ(AⅡ)水平的变化。结果:干预组 VF 发生率明显低于对照组(11.1% vs 62.5%,P<0.05)。结论:卡托普利能抑制急性心肌梗塞早期 VF 的发生,这一作用与其降低血浆 NE、AⅡ浓度和减少心肌缺血面积有关。
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| 关 键 词： | 卡托普利 家兔 急性冠脉闭塞 心室纤颤 |
Effect of Captopril on Ventricular Arrhythmias after Acute Coronary Occlusion |
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| Abstract: | Objective:To investigate the therapeutic effect of captopril on ventrieular arrhythmias and its potential mechanisms.Methods:Complete coronary ligation at the middle of left ventricular branch for 120 minutes was carried out in 17 rabbits(control group n=8;intervention group n=9).Incidence of ventricular fibrillation(VF),myocardial ischemie size,plasma levels of norepinephrine(NE)and an- giotensin Ⅱ(A Ⅱ)were observed.Results:The incidence of VF in intervention group was markedly lower than in control group(11.1% vs 62.5%,P<0.05).Conclusion:Captopril can inhibit the occurrence of VF in early stage of acute myocardial infarction and this effect may be related to the reduction in plas- ma concentrations of NE and A Ⅱ,as well as to the decrease in size of myocardial ischemia. |
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| Keywords: | captopril rabbit acute coronary occlusion ventricular fibrillation |
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