妊娠滋养细胞肿瘤子宫血管铸形研究

目的:探索妊娠滋养细胞肿瘤与子宫血管的关系。方法:甲基丙烯酸酯为铸型剂,对离体10例子宫(绒癌3例、葡萄胎2例、侵蚀性葡萄胎3例、对照2例)进行灌注,制成标本,扫描电镜观察血管的异常改变。结果:正常子宫血管分为二种类型,一是树枝状分布,二是螺旋状血管;良性葡萄胎的血管改变无明显特征;恶性滋养细胞肿瘤血管铸型立体构式,大体仍是树枝分布,螺旋血管增多,可见大片的血窦状改变血管、发夹状血管、串珠状改变及多处铸型剂漏出等血管被破坏性改变,但最为明显的改变是新生血管的出现;侵蚀性葡萄胎与绒癌的血管异常改变无明显的差异。结论:妊娠滋养细胞肿瘤在破坏子宫血管的同时,伴有新生血管的形成,为肿瘤的抗血管形成治疗提供有力证据。

Study of Uterine Vascular Casting with Gestation Trophoblastic Tumor

Objective:To explore the ralationship between gestational trophoblastic tumor(GTT)and uterine blood vessels.Methods:The uterine vacular casts in eight casts with GTT and two normal casts were made by pouring into the mixture containing mainly methyl methacrylte.The vascular stem-structure was observed,using scanding electron microscopy(SEM).Results:There were two kinds of vascular stero- structure in normal uterus.One was dendric blood vessels.The other was spiral manner.The vascular stero-structure of GTT was the same as the normal in general.It was observed that blood vessels were in- vaded and destroyed by GTT,such as toruliform vessel,large blood sinusoid and hairpin-like vessels.The most prominent expresion was angiogenesis.Conclusion:There were only not destroyed vesseles,but angio- genesis.This study provides reliable basis for GTT treatment with angiogenesis inhibitor.