L-精氨酸对高脂兔血液流变的影响

目的：本文探讨Ｌ－精氨酸对兔血脂和血流变的影响。方法：３０只雄兔随机分为以下３组：正常对照组（ＮＣ），高脂对照组（ＨＣ）和Ｌ－精氨酸组（ＬＡ），正常对照组为普通颗粒饲料组，后两组均为高胆固醇颗粒饲料组。实验开始前和实验第１０周，检测血清总胆固醇、甘油三酯和高密度脂蛋白以及血液流变各项指标。结果：实验１０周后，ＬＡ组和ＨＣ组的血清总胆固醇和甘油三酯都显著高于ＮＣ组（各为Ｐ＜０．００１），但前两组间比较无差异（Ｐ＞０．１）。治疗１０周后ＨＣ组各项血流变指标不仅明显高于实验前（各为Ｐ＜０．００１），而且显著高于ＬＡ组和ＮＣ组（Ｐ＜０．０１），但ＬＡ组和ＮＣ组血流变指标组间比较无差异（Ｐ＞０．０５）。结论：Ｌ－精氨酸不降低高脂兔血中胆固醇浓度，但明显改善其血液流变。

Effect of L arginine on Hemorrheology in Hyperlipidemic Rabbit

Objective: This study saessed the effect of L-arginine on serum lipids and hemorrheology in hyperlipidemic rabbit.Methods: Thirty male rabbits were randomly assigned to three groups of 10 each:normal control group(NC),hypercholesterolemic group(HC),and L-arginine group(LA).Before initiation of the experiment,and after 10 weeks of the treatment,blood samples were collected from rabbits in each group for measurement of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),and hemorrheology.Results: After 10 weeks of treatment,both TC and TG in the LA and the HC were significantly greater than those in the NC ( P <0.01),but there were little different between the LA and the HC ( P >0.10).All indices of hemorrheology in the HC after the 10th of experiment were significantly higher than not only those in the HC before the experiment( P <0.001),but those in both the LA and the NC after 10 weeks of treatment( P <0.01),while there were no differences between the LA and the NC in all indices of hemorrheology( P >0.05).Conclusion: L-arginine didnt lower serum TC,but obviously improved hemorrheology in hyperlipidemic rabbit.