| 姜黄素的水溶性药物递送系统的研究进展 |
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| 引用本文： | 杨汝磊,王征. 姜黄素的水溶性药物递送系统的研究进展[J]. 国际药学研究杂志, 2012, 39(4): 303-306 |
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| 作者姓名： | 杨汝磊 王征 |
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| 作者单位： | 杨汝磊 (300072天津,天津大学药物科学与技术学院,天津市现代药物传递及功能高效化重点实验室) ； 王征 (300072天津,天津大学药物科学与技术学院,天津市现代药物传递及功能高效化重点实验室) ； |
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| 基金项目： | 天津市应用与基础研究项目资助 |
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| 摘 要： | 天然活性产物姜黄素具备良好的药理学、药效学活性及用药安全性,近年来其抗肿瘤活性成为研究热点,但是姜黄素水溶性差、易降解、生物利用度低的特点限制了其应用。因此姜黄素水溶性剂型的研制与开发成为解决其临床应用的一种有效途径,本文对近年来姜黄素新剂型的研究进展进行概述。
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| 关 键 词： | 姜黄素 脂质体 聚合物胶束 前药 |
Water-soluble curcumin drug delivery system: research advances |
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| YANG Ru-lei,WANG Zheng. Water-soluble curcumin drug delivery system: research advances[J]. Foreign Medical Sciences(Section of Pharmarcy), 2012, 39(4): 303-306 |
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| Authors: | YANG Ru-lei WANG Zheng |
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| Affiliation: | (Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China) |
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| Abstract: | As a kind of natural compound,curcumin possesses perfect therapeutic activities and pharmacological safety.In particular,the significant anti-cancer activity of curcumin has greatly attracted the attention of lots of researchers in recent years.However,the characteristics of curcumin including poor water-solubility,poor stability and low bioavailability greatly limit its application.Therefore,exploring the dosage form of curcumin provides an effective way for its administration.The advances in new formulation of curcumin in recent yeas are reviewed in this paper. |
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| Keywords: | curcumin liposomes polymer micelles pro-drug |
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