Functional mechanisms of myocardial microcirculation in left ventricular hypertrophy: a hypothetical model of capillary remodeling post myocardial infarction |
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| Authors: | Waller Christiane Hiller Karl-Heinz Pfaff Daniela Gattenlöhner Stefan Ertl Georg Bauer Wolfgang R |
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| Affiliation: | Medizinische Klinik und Poliklinik I, Universit?t Würzburg, Josef-Schneider-Strasse 2, Würzburg, Germany. waller_c@medizin.uni-wuerzburg.de |
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| Abstract: | OBJECTIVES: Left ventricular (LV) remodeling after myocardial infarction (MI) is characterized by myocyte hypertrophy and a disproportional capillary growth. We developed a hypothetical model of capillary remodeling mechanisms based on quantitative data of microcirculation determined by magnetic resonance (MR) imaging techniques and histology. METHODS: Perfusion and regional capillary blood volume (RBV) were quantified 8 and 16 weeks after MI (mean 27.0+/-2.9% of the left ventricle 16 weeks post MI) or sham operation in rats using MR imaging and were correlated with morphometric data. RESULTS: Maximum perfusion (ml/(g min)) in the remote area decreased from 5.69+/-0.63 to 3.48+/-0.48 compared to sham animals (5.33+/-0.31, p
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