糖足颗粒的制备工艺研究

目的 研究糖足颗粒的制备工艺.方法 以出膏率和芍药苷总量为指标,正交试验法优选水提条件;以颗粒吸湿性、流动性和成型性为指标,筛选颗粒最佳辅料与配比.结果 最佳水提工艺为药材加10倍量水,煎煮2次,每次1.5 h;制备糖足颗粒的最优处方组成为:2份浸膏与3份辅料(乳糖:糊精=2:1的混合辅料)混合制粒.结论 该工艺科学合理,简便实用,质量稳定.

Study on the Preparation Technology of Tangzu Granula

Objective To optimize the preparation process of Tangzu Granula. Methods With the paste-forming rate and total content of paeoniflorin as the indexes, the optimal water-extraction condition was screened by orthogonal design. With hydroscopicity, fluidity and formability as the indexes, the appropriate ratio of the excipient and the formula were selected. Results The optimum water-extraction condition was as follows: 10-fold water, decoction for 2 times and 1.5 hour for each time. The optimal ratio of the excipient and the formula for preparation of Tangzu granules were two proportions of the extract and three proportions of the excipient which consisted of lactose and dextrin(2 : 1, w/ w). Conclusion The technology is effec-tive, scientific, reasonable, and practical.