香丹注射液与乳酸钠林格注射液的配伍稳定性研究

目的 考察香丹注射液与乳酸钠林格注射液配伍的稳定性，为临床安全用药提供参考。方法 按临床用药配伍使用量，制备香丹注射液与乳酸钠林格注射液的配伍溶液，考察配伍溶液的外观、pH值、不溶性微粒、紫外光谱及丹参素钠、原儿茶醛、咖啡酸、紫草酸、丹酚酸B和丹酚酸A的多指标含量。结果 香丹注射液与乳酸钠林格注射液配伍6 h内，溶液性状、pH值、紫外光谱均无显著变化，不溶性微粒呈下降趋势，丹参素钠、原儿茶醛、咖啡酸和丹酚酸B的含量无显著性变化（<3%），紫草酸含量下降了17.41%，丹酚酸A的含量下降了78.64%。结论 香丹注射液与乳酸钠林格注射液在配伍6 h内部分有效成分含量下降，建议减少配伍或配伍后尽快输注，以提高输液的有效性与安全性。

Study on Compatible Stability of Xiangdan Injection and Sodium Lactate Ringer's Injection

OBJECTIVE To investigate the compatible stability of Xiangdan injection and Sodium Lactate Ringer''s injection, and to provide reference for clinical safe medication. METHODS According to the amount of clinical application, Xiangdan injection was prepared with Sodium Lactate Ringer''s injection. The appearance of the compatibility of solution, pH value, insoluble particles, ultraviolet spectrum and the contents of the salvianolic acid sodium, protocatechuic aldehyde, caffeic acid, lithospermic acid, salvianolic acid B, salvianolic acid A were determined. RESULTS The solution properties, pH value, UV spectrum had no change and particulate matter had decreased slightly within 6 h after the compatibility of Sodium Lactate Ringer''s injection, and the content of lithospermic acid, salvianolic acid A had decreased by 17.41% and 78.64% respectively within 6 h after the compatibility of Sodium Lactate Ringer''s injection, while the other contents had no change(<3%). CONCLUSION The content of effective components decreased within 6 h after Xiangdan injection and Sodium Lactate Ringer''s injection compatibility. It is suggested not to infuse or infuse as soon as possible after compatibility to improve transfusion safety and effectiveness.