体内药物相互作用机制及其评价方法的研究进展

药物–药物相互作用是目前临床不良反应的主要来源之一,药物相互作用产生的效益和风险会严重影响药物的安全性和有效性。根据药物在体内的过程,分别从吸收、分布、代谢、排泄4个方面阐述了体内药物相互作用机制并佐以实例;潜在药物相互作用的研究以预测其可能发生的药物相互作用也已成为药物开发的必须过程,综述了近些年比较成熟的药物相互作用评价模型的及其研究进展。

Research progress of drug interaction mechanism and evaluation methods in vivo

Drug-drug interaction is one of the main sources of clinical side effects. The benefits and risks of drug interaction will seriously affect the safety and effectiveness of drugs. According to the process of drugsin vivo, this paper expounds the mechanism of drug interaction in vivo from four aspects:absorption, distribution, metabolism, and excretion; In order to predict their possible drug interactions, and to study potential drug interactions which has also been a necessary process for drug development, this paper also reviews the development and progress of relatively mature drug interaction models in recent years.