子宫内膜癌患者手术治疗前后血清 CA125、HE4和D-D水平检测的临床意义

目的 探讨了解子宫内膜癌患者手术治疗前后血清CA125、HE4和D-D水平的变化及临床意义。方法 应用放射免疫法,酶联法和免疫比浊法对31例子宫内膜癌患者进行了手术治疗前后血清CA125、HE4和D-D水平的检测,并与35名正常健康人作比较。结果 子宫内膜癌患者在手术治疗前血清CA125、HE4和D-D水平均非常显著地高于正常人组(P＜0.01),手术治疗6个月后则与正常人比较无显著性差异(P＞0.05)。血清CA125水平与HF4、D-D水平呈显著正相关,(r=0.5918、0.4725,P＜0.01)。结论 检测子宫内膜癌患者手术治疗前后血清CA125、HE4、D-D水平的变化对了解病情、观察疗效和预后判定均具有重要的临床价值.

Clinical significance of measurement of changes of serum CA125, HE4 and D-D Levels after operatim in patients with Endometrial cancer

Objective To explore the clinical significance of changes of serum CA125, HE4 and D-D levels after operation in patients with endometrial cancer. Methods Serum CA125(with RIA), HE4(with EliSA) and D-D (with immune turbility method)levels were determined in 31 patients with endometrial cancer both Before and after operatim as well as in 35 Controls. Resullts Before operation, the serum CA125,HE4 and D-D levels in the patients were significantly higher than those in controls(P<0.01). After operation for 6 months, all the levels were not significantly different from those in controls(p>0.05). Sercm CA125 levels were positively correlated with serum HE4, D-D levels (r=0.5918 0.4725 P<0.01). Conclusions The changes of serum CA125, HE4 and D-D levels after operation has important clinical value to understand the condition, observe the curative effect and the prognostic judgment.