重组人脑利钠肽治疗急性肺损伤的临床效果及对 NLRP3/6、白细胞介素水平的影响

目的 探讨重组人脑利钠肽治疗急性肺损伤的临床效果及对NLRP3/6及白细胞介素水平的影响.方法 选取2016年9月至2018年9月江南大学附属医院诊治的急性肺损伤病人80例.按照治疗方法采用随机数字表法分为对照组和观察组,每组40例.对照组给予常规治疗,观察组在对照组基础上给予重组人脑利钠肽治疗.分析两组治疗前后Murray评分及氧合指数的变化,并检测治疗前后血清中NLRP3/6及白细胞介素(IL)水平的变化.结果 对照组和观察组治疗后Murray评分(2.36±0.43)分、(1.19±0.33)分]、NLRP3(94.6±10.3)pg/mL、(77.7±11.3)pg/mL]、IL-1β(38.6±12.3)pg/mL、(30.7±12.5)pg/mL]、IL-2(42.4±12.5)pg/mL、(36.5±10.4)pg/mL]及IL-6(39.5±13.7)pg/mL、(30.8±11.6)pg/mL]水平明显降低(P<0.05),而氧合指数(283.4±18.2)、(309.4±24.3)]和NLRP6(88.9±15.1)pg/mL、(97.8±13.3)pg/mL]明显升高(P<0.05),且观察组治疗后上述项目变化更显著(P<0.05);NLRP6与急性肺损伤呈负相关性而NLRP3、IL-1β、IL-2及IL-6水平与急性肺损伤呈正相关性.结论 重组人脑利钠肽能改善急性肺损伤病人Murray评分及氧合指数效果可能与调节NLRP3/6及白细胞介素水平有关.

Clinical effect of recombinant human brain natriuretic peptide on acute lung injury and its influence on NLRP3/6 and interleukin level

Objective To analyze the clinical effects of recombinant human brain natriuretic peptide (rhBNP) on acute lung injuryand its effects on NLRP3/6 and interleukin levels.Methods Eighty patients with acute lung injury who were diagnosed and treated inAffiliated Hospital of Jiangnan University from Sep 2016 to Sep 2018 were selected as the research objects. They were randomly assigned into control group and observation group according to the treatment method, with 40 cases in each group. The patients in the control group were given routine treatment, while the patients in the observation group were treated with recombinant human brain natriuretic peptide on the basis of routine treatment. The changes of Murray score and oxygenation index in two groups before and after treatment were analyzed. The serum levels of NLRP3/6 and interleukin were measured before and after treatment.Results After treatment, Murray score (2.36±0.43) vs. (1.19±0.33)], NLRP3 (94.6±10.3) pg/mL vs. (77.7±11.3) pg/mL], IL1beta (38.6±12.3) pg/mL vs. (30.7± 12.5) pg/mL], IL2 (42.4±12.5) pg/mL vs. (36.5±10.4) pg/mL] and IL6 levels (39.5±13.7) pg/mL vs. (30.8±11.6) pg/mL] in the control group and the observation group decreased significantly (P<0.05), while oxygenation index (283.4±18.2) vs. (309.4±24.3)] and NLRP6 (88.9±15.1) pg/mL vs. (97.8±13.3) pg/mL] increased significantly (P<0.05). The changes of the above indexes were more significant in the observation group after treatment (P<0.05). NLRP6 was negatively correlated with acute lung injury, while NLRP3, IL1beta, IL2and IL6 levels were positively correlated with acute lung injury.Conclusion The effect of recombinant human brain natriuretic pep?tide on Murray score and oxygenation index in patients with acute lung injury may be related to the regulation of NLRP3 / 6 and interleukin level.