乳腺癌区域血流灌注和代谢与血管生成的关系

目的 探讨乳腺癌区域血流灌注和代谢与血管生成的关系.方法 应用PET/CT血流灌注成像和代谢成像技术分别定量检测33例乳腺癌患者肿瘤中心区域和边缘区域的血流灌注指标血流量(BF)、血容量(BV)和表面渗透性(Ps)以及代谢指标标准摄取值(SUV);采用免疫组织化学的方法检测术后肿瘤标本CD31、CD105和VEGF的表达,计算其相应的微血管密度MVD(CD31)和MVD(CD105).分析区域血流灌注和代谢指标与MVD(CD31)、MVD(CD105)和VEGF表达的关系.结果MVD(CD31)仅与肿瘤边缘区域的BF相关(P<0.05);MVD(CD105)与肿瘤中心和边缘区域BF、PS以及SUV均相关(P<0.05),而与BV无关(P>0.05).结论 乳腺癌区域血流灌注和代谢的高低与血管生成有关,通过PET/CT所获得的肿瘤区域血流灌注和代谢结果可反映肿瘤的血管生成状态.

Regional blood perfusion, metabolism and angiogenesis of breast cancer

Objective To evaluate the correlation between regional blood perfusion,metabolism and angiogenesis in breast cancer.Methods The PET/CT functional imaging technique was applied to quantitatively detect the central and marginal blood perfusion parameters including blood flow(BF),blood volume(BV)and permeability of surface(Ps),and metabolism index of standard uptake value(SUV)of the tumor in 33 breast cancer patients.The expression of CD31.CD105 and VEGF in paraffin section of breast cancer were detected by immunohistochemical method,then MVD(CD31)and MVD(CD105)were obtained.The relationship between the regional blood perfusion and metabolism and MVD(CD3 1),MVD(CD105)and the expression of VEGF were analyzed. Results There was significant correlation of MVD (CD31)with BF of marginal region(P<0.05).There were significant correlations of MVD(CD105)with BF.PS and SUV(P<0.05). Conclusions Regional blood perfusion,metabolism is correlated with angiogenesis in breast cancer tissue.PETT/CT regional blood perfusion and metabolic imaging iS a noninvasive method which can be used to estimate angiogenesis status clinically in breast cancer.