| 90Sr-90Y对人良性前列腺增生细胞增殖与凋亡影响的研究 |
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| 引用本文： | 张彤,魏巍,邹本杰,刘芳,徐祗顺. 90Sr-90Y对人良性前列腺增生细胞增殖与凋亡影响的研究[J]. 中华放射医学与防护杂志, 2003, 23(2): 98-99 |
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| 作者姓名： | 张彤 魏巍 邹本杰 刘芳 徐祗顺 |
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| 作者单位： | 张彤（天津医科大学）;徐祗顺（山东大学齐鲁医院）;魏巍（250031,济南,山东省交通医院泌尿外科）;邹本杰（250031,济南,山东省交通医院泌尿外科）;刘芳（250031,济南,山东省交通医院泌尿外科） |
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| 摘 要： | 目的探讨放射性核素
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| 关 键 词： | 前列腺增生 细胞增殖 细胞凋亡 放射性核素 ^90Sr－^90Y DNA原位末端标记法 免疫组织化学 |
| 收稿时间： | 2002-05-12 |
| 修稿时间： | 2002-05-12 |
Study of radionuclide 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia |
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| ZHANG Tong,XU Zhishun,WEI Wei. Study of radionuclide 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia[J]. Chinese Journal of Radiological Medicine and Protection, 2003, 23(2): 98-99 |
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| Authors: | ZHANG Tong XU Zhishun WEI Wei |
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| Affiliation: | Department of Urology, Shandong Traffic Hospital, Jinan 250031, China;Department of Urology, Shandong Traffic Hospital, Jinan 250031, China;Department of Urology, Shandong Traffic Hospital, Jinan 250031, China;Department of Urology, Shandong Traffic Hospital, Jinan 250031, China |
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| Abstract: | Objective To investigate the effect of 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia. Methods The apoptosis and expression of Ki-67 in benign prostatic hyperplasia (BPH) before and after irradiation 90Sr-90Y were detected by transferase-mediated dUTP-biotin nick end labeling (TUNEL) method and immunohistochemical technique, respectively. Results The proliferation index (PI) of BPH after 90Sr-90Y irradiation was much lower than that before irradiation, but there was no significant change in apoptosis index (AI). Conclusion Irradiation with 90Sr-90Y could restrain cell proliferation of BPH, but could not induce apoptosis. |
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| Keywords: | 90Sr-90Y Benign prostatic hyperplasia Proliferation Apoptosis |
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