| Abstract: | In experiments on rats forced to swim while carrying a load, sodium hydroxybutyrate was found to have a normalizing effect on the ammonia content in the striated muscles, a biochemical indicator of physical fatigue. Whereas in control rats not receiving hydroxybutyrate swimming led to a marked (more than twofold) increase in the ammonia content in muscle tissue, in animals receiving prophylactic sodium hydroxybutyrate (one only or as a 2-week course) ammonia did not accumulate. It is suggested that by preventing the toxic effect of one of the end products of nitrogen metabolism, sodium hydroxybutyrate may alleviate the after-effects of muscular fatigue.Laboratory of Pharmacology of the Nervous System, Institute, of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 1, pp. 25–27, January, 1980. |
