SREPS对肝癌H22荷瘤小鼠的抑瘤作用

目的研究硫酸酯化细菌胞外多糖SREPS对肝癌H22荷瘤小鼠的抑瘤作用。方法70只肝癌H22荷瘤小鼠随机分为7组：模型组、SREPS不同剂量组（0．5，1，2．5，5，10ms／kg）和环磷酰胺组，腹腔注射，1次／d，连续10d。于造模第11天观察抑瘤率、胸腺指数和脾指数。结果SREPS不同剂量组（0．5，1，2．5，5，10mg／kg）的抑瘤率分别为21．60％、23。50％，34．90％，26．50％和28．92％。与模型组比较，除0．5mg／kg外，其余各浓度的瘤质量显著降低（P〈0．05）；SREPS不同剂量组可增加荷瘤小鼠的胸腺指数和脾指数，其中2．5mg／kg剂量组对荷瘤小鼠胸腺指数和脾指数均显著增加（P〈0．05）。结论SREPS对肝癌H22荷瘤小鼠有一定的抑瘤作用，SRESP在抑制肿瘤的同时可提高荷瘤小鼠的免疫功能。

Inhibitory effect of SREPS against H22 tumor-bearing mice

Objective To evaluate the inhibitory effect of sulfated rhizobium exopolysaccharide （SREPS） against the H22 tumor - bearing mice. Methods H22 tumor-bearing mice were randomly divided into model group, cyclophosphamide group, SREPS groups （0.5,1,2.5,5,10 mg/kg）. After 10 d treatment,the inhibitive rate,thymus index and spleen index were observed and recorded. Re- sults The inhibitory rates respectively were 21.60%,23.50%,34.90%,26.50% and 28.92% after treated with 0.5,1,2.5,5,10 mg/ kg SREPS ,respectively. Compared with model group,the weight of tumor significantly decreased in SREPS groups except 0.5 mg/kg（ P 〈 0.05 ）. Compared with model group, the weight of immune organs and the spleen and thymus index significantly increased in SREPS groups, especially in 2.5 mg/kg group. Conclusion SREPS have inhibitory effect on H22 growth in tumor-bearing mice, and can improve the immune function.