| 非小细胞肺癌314例EGFR基因突变的研究 |
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| 引用本文： | 田辉,于凯忠,毛争春,金成华,潘海彬,杨曦,黄晓燕,沈韦羽.非小细胞肺癌314例EGFR基因突变的研究[J].山西医学院学报,2014(6):465-467. |
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| 作者姓名： | 田辉 于凯忠 毛争春 金成华 潘海彬 杨曦 黄晓燕 沈韦羽 |
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| 作者单位： | [1]宁波市医疗中心李惠利医院胸外科,宁波315041 [2]宁波市医疗中心李惠利医院中心实验室,宁波315041 |
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| 摘 要： | 目的研究中国人非小细胞肺癌表皮生长因子受体（EGFR）基因突变的情况及其与临床特征（性别、临床分期、吸烟情况）的关系。方法采用PCR扩增和基因测序检测314例非小细胞肺癌（NSCLCs）EGFR外显子19和21的突变情况，分析其突变与临床特征的关系。结果314例中共检测出120例（38．2％）EGFR突变，EGFR基因突变与性别和吸烟史相关，与临床分期无关。结论中国人NSCLCs的EGFR突变率较高，在使用EGFR酪氨酸激酶抑制剂治疗前进行EGFR基因突变检测很有必要。
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| 关 键 词： | 表皮生长因子受体 非小细胞肺癌 基因突变 |
Study on mutation of EGFR gene in 314 cases of non-small cell lung cancers |
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| Authors: | TIAN Hui YU Kaizhong MAO Zhengchun JIN Chenghua PAN Haibin YANG Xi HUANG Xiaoyan SHEN Weiyu |
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| Institution: | 1 Department of Thoracic Surgery, Lihuili Hospital of Ningbo Medical Center, Ningbo 315041, China; 2 Center Laboratory, Lihuili Hospital of Ningbo Medical Center ) |
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| Abstract: | Objective To investigate gene mutations of epidermal growth factor receptor （EGFR） in Chinese non-small cell lung cancers（NSCLCs）. Methods Mutations of exons 19 and 21 of EGFR in 314 NSCLCs were detected by PCR amplification and gene sequencing,and the relationships between mutations and clinical features of NSCLCs were analyzed. Results Overall 120 EGFR mu- tations（38.2% ）were detected in 314 cases, and the mutation was related to sex and history of smoking, but not related to the clinical stage. Conclusion Due to high mutation frequency of EGFR in Chinese NSCLC patients,it is highly recommended to investigate GE- FR gene mutations before treatment with tyrosine kinase inhibitors. |
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| Keywords: | epidermal growth factor receptor non-small cell lung cancer gene mutation |
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